Academic Journal
KRAB-ZFPs and cancer stem cells identity
| العنوان: | KRAB-ZFPs and cancer stem cells identity |
|---|---|
| المؤلفون: | Anna Olechnowicz, Urszula Oleksiewicz, Marta Machnik |
| المصدر: | Genes and Diseases, Vol 10, Iss 5, Pp 1820-1832 (2023) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Genetics |
| مصطلحات موضوعية: | Cancer, Cancer stem cell, Epigenetic, KRAB-ZFP, Transcription factors, Medicine (General), R5-920, Genetics, QH426-470 |
| الوصف: | Studies on carcinogenesis continue to provide new information about different disease-related processes. Among others, much research has focused on the involvement of cancer stem cells (CSCs) in tumor initiation and progression. Studying the similarities and differences between CSCs and physiological stem cells (SCs) allows for a better understanding of cancer biology. Recently, it was shown that stem cell identity is partially governed by the Krϋppel-associated box domain zinc finger proteins (KRAB-ZFPs), the biggest family of transcription regulators. Several KRAB-ZFP factors exert a known effect in tumor cells, acting as tumor suppressor genes (TSGs) or oncogenes, yet their role in CSCs is still poorly characterized. Here, we review recent studies regarding the influence of KRAB-ZFPs and their cofactor protein TRIM28 on CSCs phenotype, stemness features, migration and invasion potential, metastasis, and expression of parental markers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352304222000873; https://doaj.org/toc/2352-3042 |
| DOI: | 10.1016/j.gendis.2022.03.013 |
| URL الوصول: | https://doaj.org/article/8abbb49ab4ce4c82b1d934409a64f24d |
| رقم الانضمام: | edsdoj.8abbb49ab4ce4c82b1d934409a64f24d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523042 |
|---|---|
| DOI: | 10.1016/j.gendis.2022.03.013 |