Academic Journal
IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
| العنوان: | IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY |
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| المؤلفون: | N. V. Korneva, A. A. Starshinova, Yu. E. Ovchinnikova, E. I. Potapenko, O. A. Yakunova, I. F. Dovgalyuk |
| المصدر: | Медицинская иммунология, Vol 16, Iss 5, Pp 425-430 (2014) |
| بيانات النشر: | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | tuberculosis, children, immunity, diaskintest®, quantiferon tb-gold, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Two-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and immunologic assessment. All the patients were examined by DIASKINTEST® (DST) and QuantiferonTB Gold (QFT-G). They were divided into 2 groups, as based on laboratory data, as follows: group I (n= 63), patients with negative DST and QFT-G results; group II (n = 148), with positive results of specific tests. The study was aimed for intergroup comparisons of immune response markers. Positive results of DST and QFT-G suggested clinical activity of tuberculosis infection and are associated with high scores of tuberculin skin test (TST); increased cytokine levels (TNFα, IL-2, IFNγ), higher percentage of CD3+, CD4+ и CD95+ cells, elevated levels of specific IgG antibodies (anda TB ELISA); high titers of complement fixation test for mycobacteria, and activation of neutrophils. Positive results of DST and QFT-G in the patients are more often associated with active infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1563-0625 2313-741X |
| Relation: | https://www.mimmun.ru/mimmun/article/view/728; https://doaj.org/toc/1563-0625; https://doaj.org/toc/2313-741X |
| DOI: | 10.15789/1563-0625-2014-5-425-430 |
| URL الوصول: | https://doaj.org/article/8a0d9bef62d74b55ab506a9a883a9708 |
| رقم الانضمام: | edsdoj.8a0d9bef62d74b55ab506a9a883a9708 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 15630625 2313741X |
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| DOI: | 10.15789/1563-0625-2014-5-425-430 |