التفاصيل البيبلوغرافية
| العنوان: |
Characterisation of the Interaction among Oil-In-Water Nanocapsules and Mucin |
| المؤلفون: |
Mar Collado-González, Gurmeet Kaur, Yadira González-Espinosa, Rebecca Brooks, Francisco M. Goycoolea |
| المصدر: |
Biomimetics, Vol 5, Iss 3, p 36 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Technology |
| مصطلحات موضوعية: |
mucin, oil-in-water nanoparticles, chitosan, stability, ζ-potential, quorum sensing, Technology |
| الوصف: |
Mucins are glycoproteins present in all mucosal surfaces and in secretions such as saliva. Mucins are involved in the mucoadhesion of nanodevices carrying bioactive molecules to their target sites in vivo. Oil-in-water nanocapsules (NCs) have been synthesised for carrying N,N′-(di-m-methylphenyl)urea (DMTU), a quorum-sensing inhibitor, to the oral cavity. DMTU-loaded NCs constitute an alternative for the treatment of plaque (bacterial biofilm). In this work, the stability of the NCs after their interaction with mucin is analysed. Mucin type III from Sigma-Aldrich has been used as the mucin model. Mucin and NCs were characterised by the multi-detection asymmetrical flow field-flow fractionation technique (AF4). Dynamic light scattering (DLS) and ζ-potential analyses were carried out to characterise the interaction between mucin and NCs. According to the results, loading DMTU changes the conformation of the NC. It was also found that the synergistic interaction between mucin and NCs was favoured within a specific range of the mucin:NC ratio within the first 24 h. Studies on the release of DMTU in vitro and the microbial activity of such NCs are ongoing in our lab. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2313-7673 |
| Relation: |
https://www.mdpi.com/2313-7673/5/3/36; https://doaj.org/toc/2313-7673 |
| DOI: |
10.3390/biomimetics5030036 |
| URL الوصول: |
https://doaj.org/article/8a07adbce654491fadbfea167f4ae941 |
| رقم الانضمام: |
edsdoj.8a07adbce654491fadbfea167f4ae941 |
| قاعدة البيانات: |
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