Academic Journal
Combined analysis of whole blood interferon gamma release assay and complete blood count analysis for rapid discrimination of active tuberculosis and latent tuberculosis infection
| العنوان: | Combined analysis of whole blood interferon gamma release assay and complete blood count analysis for rapid discrimination of active tuberculosis and latent tuberculosis infection |
|---|---|
| المؤلفون: | Yun-Jeong Kang, Heechul Park, Sung-Bae Park, Junseong Kim, Jiyoung Lee, Jungho Kim, Sunyoung Park, Yong Sung Lee, Sunghyun Kim |
| المصدر: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 24, Iss , Pp 100253- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the respiratory system LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Active tuberculosis, Latent tuberculosis infection, Complete blood count, White blood cell differential count, Biomarker, Diseases of the respiratory system, RC705-779, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (MTB), is a serious infectious disease with high infection and mortality rates and is a public health problem around the world. According to the World Health Organization (WHO) report, one-third of the world's population is latently infected with MTB, and 5 to 10% of those with latent TB infection (LTBI) have the potential to develop active TB once in their lifetime. Therefore, TB management for promptly distinguishing LTBI from active TB and for proper treatment is important. LTBI is currently diagnosed using the tuberculin skin test (TST) and interferon gamma (IFN-γ) release assay (IGRA). However, this test is substantially limited by its inability to distinguish active TB from LTBI. It is necessary to discover indicators that can be used for effective TB management and to develop diagnostic methods. In the present study, we used IGRA and complete blood count (CBC) analysis for discrimination of active TB, LTBI, and healthy control groups. The results showed that the number of WBC was significantly increased in the group with active TB (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-5794 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405579421000425; https://doaj.org/toc/2405-5794 |
| DOI: | 10.1016/j.jctube.2021.100253 |
| URL الوصول: | https://doaj.org/article/89c8db1db7af4066b5f8de05e7d85da4 |
| رقم الانضمام: | edsdoj.89c8db1db7af4066b5f8de05e7d85da4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24055794 |
|---|---|
| DOI: | 10.1016/j.jctube.2021.100253 |