Academic Journal
Causality and independence in perfectly adapted dynamical systems
| العنوان: | Causality and independence in perfectly adapted dynamical systems |
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| المؤلفون: | Blom Tineke, Mooij Joris M. |
| المصدر: | Journal of Causal Inference, Vol 11, Iss 1, Pp 203-24 (2023) |
| بيانات النشر: | De Gruyter, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Mathematics LCC:Probabilities. Mathematical statistics |
| مصطلحات موضوعية: | causal ordering, causal discovery, feedback, equilibrium, perfect adaptation, 37c20, 60g99, 62a01, 62a09, 62d20, 62h22, 62m99, 92c42, 92c45, 93c73, Mathematics, QA1-939, Probabilities. Mathematical statistics, QA273-280 |
| الوصف: | Perfect adaptation in a dynamical system is the phenomenon that one or more variables have an initial transient response to a persistent change in an external stimulus but revert to their original value as the system converges to equilibrium. With the help of the causal ordering algorithm, one can construct graphical representations of dynamical systems that represent the causal relations between the variables and the conditional independences in the equilibrium distribution. We apply these tools to formulate sufficient graphical conditions for identifying perfect adaptation from a set of first-order differential equations. Furthermore, we give sufficient conditions to test for the presence of perfect adaptation in experimental equilibrium data. We apply this method to a simple model for a protein signalling pathway and test its predictions in both simulations and using real-world protein expression data. We demonstrate that perfect adaptation can lead to misleading orientation of edges in the output of causal discovery algorithms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-3685 |
| Relation: | https://doaj.org/toc/2193-3685 |
| DOI: | 10.1515/jci-2021-0005 |
| URL الوصول: | https://doaj.org/article/e89bacf28d3941ebb1efe05dd970d38f |
| رقم الانضمام: | edsdoj.89bacf28d3941ebb1efe05dd970d38f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21933685 |
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| DOI: | 10.1515/jci-2021-0005 |