التفاصيل البيبلوغرافية
| العنوان: |
Primary tracheal synovial sarcoma: a rare clinical entity with diagnostic challenges |
| المؤلفون: |
Navin Kumar, Seema Kaushal, Kanaklata Kanaklata, Manoj Gowda, Sunil Kumar |
| المصدر: |
Journal of the Egyptian National Cancer Institute, Vol 32, Iss 1, Pp 1-6 (2020) |
| بيانات النشر: |
SpringerOpen, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Tracheal tumors, Synovial sarcoma, Tracheal resection, Tracheoplasty, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Background The incidence of primary tracheal tumors is very low. Tracheal synovial sarcoma (SS) is even an extremely rare entity. Diagnosis of tracheal SS can be achieved with chromosomal translocation studies along with immunohistochemistry. Margin-free resection is the gold standard treatment. Case presentation We report a case of tracheal SS, which presented with stridor with a history of chronic cough and was diagnosed with a battery of clinical investigations and managed successfully with tracheal resection surgery. In histology, it may mimic Ewing’s sarcoma. Immunohistochemically, SS stains positive for cytokeratin, epithelial membrane antigen, vimentin, and S100. Chromosomal translocation t(X;18) (p11;q11) is found in almost all SS. This genetic signature is the gold standard diagnostic modality for these tumors. Conclusion Diagnosis of tracheal synovial sarcoma is challenging because of the rarity of the disease and common presenting symptoms to other tracheal pathology and is supplemented with chromosomal translocation study along with histopathology and immunohistochemistry. Tumor coring before definite surgical resection facilitates lung perfusion in obstructive tracheal pathology. A multidisciplinary team approach for diagnosis and management along with long-term follow-up are warranted. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0409 |
| Relation: |
https://doaj.org/toc/2589-0409 |
| DOI: |
10.1186/s43046-019-0014-z |
| URL الوصول: |
https://doaj.org/article/ea89ba07612a4e148a974819f777012d |
| رقم الانضمام: |
edsdoj.89ba07612a4e148a974819f777012d |
| قاعدة البيانات: |
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