التفاصيل البيبلوغرافية
| العنوان: |
MNRR1 is a driver of ovarian cancer progression |
| المؤلفون: |
Hussein Chehade, Neeraja Purandare, Alexandra Fox, Nicholas Adzibolosu, Shawn Jayee, Aryan Singh, Roslyn Tedja, Radhika Gogoi, Siddhesh Aras, Lawrence I. Grossman, Gil Mor, Ayesha B. Alvero |
| المصدر: |
Translational Oncology, Vol 29, Iss , Pp 101623- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Ovarian cancer, MNRR1, Spheroid formation, Focal adhesion, ECM, Cytoskeleton, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Cancer progression requires the acquisition of mechanisms that support proliferative potential and metastatic capacity. MNRR1 (also CHCHD2, PARK22, AAG10) is a bi-organellar protein that in the mitochondria can bind to Bcl-xL to enhance its anti-apoptotic function, or to respiratory chain complex IV (COX IV) to increase mitochondrial respiration. In the nucleus, it can act as a transcription factor and promote the expression of genes involved in mitochondrial biogenesis, migration, and cellular stress response. Given that MNRR1 can regulate both apoptosis and mitochondrial respiration, as well as migration, we hypothesize that it can modulate metastatic spread. Using ovarian cancer models, we show heterogeneous protein expression levels of MNRR1 across samples tested and cell-dependent control of its stability and binding partners. In addition to its anti-apoptotic and bioenergetic functions, MNRR1 is both necessary and sufficient for a focal adhesion and ECM repertoire that can support spheroid formation. Its ectopic expression is sufficient to induce the adhesive glycoprotein THBS4 and the type 1 collagen, COL1A1. Conversely, its deletion leads to significant downregulation of these genes. Furthermore, loss of MNRR1 leads to delay in tumor growth, curtailed carcinomatosis, and improved survival in a syngeneic ovarian cancer mouse model. These results suggest targeting MNRR1 may improve survival in ovarian cancer patients. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1936-5233 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1936523323000086; https://doaj.org/toc/1936-5233 |
| DOI: |
10.1016/j.tranon.2023.101623 |
| URL الوصول: |
https://doaj.org/article/89a8bc8b63a84bbfb5fbfc3aa920eddc |
| رقم الانضمام: |
edsdoj.89a8bc8b63a84bbfb5fbfc3aa920eddc |
| قاعدة البيانات: |
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