Academic Journal
Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae
| العنوان: | Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae |
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| المؤلفون: | Ignacio Fernández-Pastor, Victor González-Menéndez, Frederick Annang, Clara Toro, Thomas A. Mackenzie, Cristina Bosch-Navarrete, Olga Genilloud, Fernando Reyes |
| المصدر: | Pharmaceuticals, Vol 14, Iss 3, p 268 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | pipecolisporin, Nigrospora oryzae, fungal endophyte, structural elucidation, Marfey’s analysis, antiparasitic activity, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte isolated from roots of Triticum sp. collected in a traditional agricultural land of Montefrío, Granada, Spain. The structure of this compound, including its absolute configuration, was elucidated by HRMS, 1-D and 2-D NMR spectroscopy, and Marfey’s analysis. This metabolite displayed interesting activity against Plasmodium falciparum and Trypanosoma cruzi, with IC50 values in the micromolar range, and no significant cytotoxicity against the human cancer cell lines A549, A2058, MCF7, MIA PaCa-2, and HepG2. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14030268 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/14/3/268; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph14030268 |
| URL الوصول: | https://doaj.org/article/897cfac6364e4723b639884aefc694ab |
| رقم الانضمام: | edsdoj.897cfac6364e4723b639884aefc694ab |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14030268 14248247 |
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| DOI: | 10.3390/ph14030268 |