Academic Journal
Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review
| العنوان: | Effectiveness of the pre-Omicron COVID-19 vaccines against Omicron in reducing infection, hospitalization, severity, and mortality compared to Delta and other variants: A systematic review |
|---|---|
| المؤلفون: | Pradipta Paul, Ahmed El-Naas, Omar Hamad, Mohammad A. Salameh, Nada Mhaimeed, Ibrahim Laswi, Ali A. Abdelati, Jamal AlAnni, Bushra Khanjar, Dana Al-Ali, Krishnadev V. Pillai, Abdallah Elshafeey, Hasan Alroobi, Zain Burney, Omar Mhaimeed, Mohammad Bhatti, Pratyaksha Sinha, Muna Almasri, Ahmed Aly, Khalifa Bshesh, Reem Chamseddine, Omar Khalil, Ashton D’Souza, Thanu Shree, Narjis Mhaimeed, Lina Yagan, Dalia Zakaria |
| المصدر: | Human Vaccines & Immunotherapeutics, Vol 19, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | omicron, delta, alpha, sars-cov-2, covid-19, effectiveness, vaccine, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Despite widespread mass rollout programs, the rapid spread of the SARS-CoV-2 Omicron variant called into question the effectiveness of the existing vaccines against infection, hospitalization, severity, and mortality compared to previous variants. This systematic review summarizes and compares the effectiveness of the COVID-19 vaccines, with respect to the above outcomes in adults, children, and adolescents. A comprehensive literature search was undertaken on several databases. Only 51 studies met our inclusion criteria, revealing that the protection from primary vaccination against Omicron infection is inferior to protection against Delta and Alpha infections and wanes faster over time. However, mRNA vaccine boosters were reported to reestablish effectiveness, although to a lower extent against Omicron. Nonetheless, primary vaccination was shown to preserve strong protection against Omicron-associated hospitalization, severity, and death, even months after last dose. However, boosters provide more robust and longer-lasting protection against hospitalizations due to Omicron as compared to only primary series. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2164-5515 2164-554X 21645515 |
| Relation: | https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X |
| DOI: | 10.1080/21645515.2023.2167410 |
| URL الوصول: | https://doaj.org/article/8901f20092b34bae9da27efb77b69567 |
| رقم الانضمام: | edsdoj.8901f20092b34bae9da27efb77b69567 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21645515 2164554X |
|---|---|
| DOI: | 10.1080/21645515.2023.2167410 |