التفاصيل البيبلوغرافية
| العنوان: |
Stable Isotope Abundance and Fractionation in Human Diseases |
| المؤلفون: |
Illa Tea, Arnaud De Luca, Anne-Marie Schiphorst, Mathilde Grand, Sophie Barillé-Nion, Eric Mirallié, Delphine Drui, Michel Krempf, Régis Hankard, Guillaume Tcherkez |
| المصدر: |
Metabolites, Vol 11, Iss 6, p 370 (2021) |
| بيانات النشر: |
MDPI AG, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
isotope effect, fractionation, metabolic partitioning, diabetes, cancer, metal homeostasis, Microbiology, QR1-502 |
| الوصف: |
The natural abundance of heavy stable isotopes (13C, 15N, 18O, etc.) is now of considerable importance in many research fields, including human physiology. In fact, it varies between tissues and metabolites due to isotope effects in biological processes, that is, isotope discriminations between heavy and light isotopic forms during enzyme or transporter activity. The metabolic deregulation associated with many diseases leads to alterations in metabolic fluxes, resulting in changes in isotope abundance that can be identified easily with current isotope ratio technologies. In this review, we summarize the current knowledge on changes in natural isotope composition in samples (including various tissues, hair, plasma, saliva) found in patients compared to controls, caused by human diseases. We discuss the metabolic origin of such isotope fractionations and highlight the potential of using isotopes at natural abundance for medical diagnosis and/or prognostic. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2218-1989 |
| Relation: |
https://www.mdpi.com/2218-1989/11/6/370; https://doaj.org/toc/2218-1989 |
| DOI: |
10.3390/metabo11060370 |
| URL الوصول: |
https://doaj.org/article/d8872be9b990463aad90726b7354c5b6 |
| رقم الانضمام: |
edsdoj.8872be9b990463aad90726b7354c5b6 |
| قاعدة البيانات: |
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