Academic Journal
Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis
| العنوان: | Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis |
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| المؤلفون: | Florence Man Fung Cheung, Chit Chow, Jimmy Yu Wai Chan |
| المصدر: | Clinical Case Reports, Vol 11, Iss 6, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | CSF1, eosinophilia, Langerhans cells, Sclerosing mucoepidermoid carcinoma, Medicine, Medicine (General), R5-920 |
| الوصف: | Key Clinical Message When faced with a slowly enlarging firm mass in the parotid gland accompanied by a histological picture of unusual sclerosis with abundant Langerhans cells and eosinophilic infiltrates, sclerosing mucoepidermoid carcinoma with eosinophilia should be considered as one of the differential diagnoses. Further studies are warranted for accurate diagnosis and appropriate treatment. Abstract Sclerosing mucoepidermoid carcinoma of the salivary gland with eosinophilia is a rare tumor mostly negative for the MAML2 rearrangement commonly seen in salivary mucoepidermoid carcinoma. It was not listed as an entity in the 2022 WHO Classification of Head and Neck Tumors. We presented one case initially diagnosed as Langerhans cell histiocytosis and recurred as a frankly invasive carcinoma. Molecular studies showed CSF1 gene derangement and provided new understanding concerning the Langerhans cell and eosinophilic reaction. Further molecular studies on this entity would throw light on its oncogenesis and refine its nomenclature. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-0904 |
| Relation: | https://doaj.org/toc/2050-0904 |
| DOI: | 10.1002/ccr3.7488 |
| URL الوصول: | https://doaj.org/article/8838bd36b4d147ca96c56bdbc7c7fd14 |
| رقم الانضمام: | edsdoj.8838bd36b4d147ca96c56bdbc7c7fd14 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20500904 |
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| DOI: | 10.1002/ccr3.7488 |