Academic Journal
The Frequency and the Significance of TNF-α+CD19+ B-cell Population in Lymph Nodes of Patients with Squamous Cell Carcinoma of Head and Neck
| العنوان: | The Frequency and the Significance of TNF-α+CD19+ B-cell Population in Lymph Nodes of Patients with Squamous Cell Carcinoma of Head and Neck |
|---|---|
| المؤلفون: | Marzieh Norouzian, Fereshteh Mehdipour, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi |
| المصدر: | Turkish Journal of Immunology, Vol 12, Iss 2, Pp 77-83 (2024) |
| بيانات النشر: | Galenos Publishing House, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | b-cells, il-10, scc of the head and neck tnf-α, tumor draining lymph nodes, Medicine |
| الوصف: | Objective: B-cells can contribute to the suppression or progression of the tumor growth through the secretion of various cytokines. In this study, the relevance of B-cell cytokine production to the outcome variables in patients having squamous cell carcinoma (SCC) of the head and neck was studied. Materials and Methods: Thirty-six draining lymph nodes from untreated patients with tongue and larynx SCC were stimulated with CpG, recombinant CD40L and phorbol-12-myristate-13-acetate/ionomycin and analyzed by flow cytometry for the frequency of B-cell subsets based on interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-α) cytokine production. Results: It was indicated that patients with uninvolved lymph nodes and low stage of the disease had an increased percentage of TNF-α+CD19+ B-cells (p=0.006 and p=0.041, respectively), whereas the frequency of IL-10+CD19+ B-cells showed an increasing trend in tumor-draining lymph nodes (TDLNs) of patients with grade 2+3 compared to grade 1 (p=0.054). Conclusion: Collectively, TNF-α-producing B-cells in TDLNs has been reported to be associated with good prognosticators in patients with SCC of head and neck that might have a positive role in immunity to SCC of head and neck. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1301-109X 2147-8325 |
| Relation: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-19480; https://doaj.org/toc/1301-109X; https://doaj.org/toc/2147-8325 |
| DOI: | 10.4274/tji.galenos.2024.19480 |
| URL الوصول: | https://doaj.org/article/87c3e49ef26a4a11a2168e44df4089d1 |
| رقم الانضمام: | edsdoj.87c3e49ef26a4a11a2168e44df4089d1 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 1301109X 21478325 |
|---|---|
| DOI: | 10.4274/tji.galenos.2024.19480 |