التفاصيل البيبلوغرافية
| العنوان: |
Proton MR Spectroscopy in leukodystrophies |
| المؤلفون: |
Eman Muhammad Abdelsalam, Germeen Albeir Ashamallah, Mahmoud Abdel Lateef, Khaled Fathy |
| المصدر: |
The Egyptian Journal of Radiology and Nuclear Medicine, Vol 46, Iss 4, Pp 1091-1097 (2015) |
| بيانات النشر: |
SpringerOpen, 2015. |
| سنة النشر: |
2015 |
| المجموعة: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| مصطلحات موضوعية: |
Spectroscopy, Leukodystrophies, MRI, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| الوصف: |
Objective: To analyze MR Spectroscopic findings and metabolite ratios in regions of abnormal signal in children with leukodystrophies. Methods: This prospective study was carried out on twenty-six children (17 males and 9 females); median age, 36 months ± 54 inter-quartile range. The imaging protocol included axial T1 and T2-weighted spin-echo and FLAIR images, and coronal and sagittal T2-weighted spin-echo images. 1H-MRSI was performed during the same session for all patients. Spectra were acquired from a volume of interest in the affected white matter and intravoxel (NAA/Cr, Cho/Cr, and Cho/NAA) ratios were calculated. Results: Spectroscopic analysis revealed abnormal (NAA/Cr, Cho/Cr, and Cho/NAA) ratios. Some were highly characteristic and specific as markedly elevated NAA resonance peak in cases with Canavan’s disease and significantly elevated lactate resonance peak in Leigh disease and MELAS syndrome. In the majority of cases, elevated Cho/Cr, decreased NAA/Cr and elevated Cho/NAA ratios were the dominant finding. One-way analysis of variance for the spectroscopic metabolite ratios revealed statistical significance (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0378-603X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0378603X15001941; https://doaj.org/toc/0378-603X |
| DOI: |
10.1016/j.ejrnm.2015.08.013 |
| URL الوصول: |
https://doaj.org/article/87a28f3e7e6f44889e0ca5059cc662c5 |
| رقم الانضمام: |
edsdoj.87a28f3e7e6f44889e0ca5059cc662c5 |
| قاعدة البيانات: |
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