التفاصيل البيبلوغرافية
| العنوان: |
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma |
| المؤلفون: |
Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux |
| المصدر: |
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| بيانات النشر: |
Nature Portfolio, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target which mediates chemotherapy resistance through increased expression of DNA repair associated genes. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-34179-8 |
| URL الوصول: |
https://doaj.org/article/875e347a38ed42f697dc3427cce904d4 |
| رقم الانضمام: |
edsdoj.875e347a38ed42f697dc3427cce904d4 |
| قاعدة البيانات: |
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