Academic Journal
A Simple and Sensitive HPLC Method for Simultaneous Analysis of Nabumetone and Paracetamol in Pharmaceutical Formulations
| العنوان: | A Simple and Sensitive HPLC Method for Simultaneous Analysis of Nabumetone and Paracetamol in Pharmaceutical Formulations |
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| المؤلفون: | Prafulla Kumar Sahu, M. Mathrusri Annapurna, Dillipkumar Sahoo |
| المصدر: | E-Journal of Chemistry, Vol 8, Iss S1, Pp S41-S46 (2011) |
| بيانات النشر: | Wiley, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Chemistry, QD1-999 |
| الوصف: | This paper describes a high-performance liquid chromatographic method for simultaneous estimation of nabumetone and paracetamol in binary mixture. The method was based on RP-HPLC separation and quantitation of the two drugs on hypersil C-18 column (250 mm × 4.6 mm) using a mobile phase consisting of acetonitrile and 0.05% aqueous acetic acid (70:30v/v) at flow rate of 1 mL min-1. Quantitation was achieved with PDA detector at 238 nm based on peak area with linear calibration curves at concentration ranges 5-25 µg mL-1 for both the drugs. Naproxen sodium was used as internal standard. The method has been successively applied to pharmaceutical formulation. No chromatographic interference from the tablet excipients was found. The method was validated in terms of precision, robustness, recovery and limits of detection and quantitation. The intra and inter-day precision and accuracy values were in the acceptance range as per ICH guidelines. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0973-4945 2090-9810 |
| Relation: | https://doaj.org/toc/0973-4945; https://doaj.org/toc/2090-9810 |
| DOI: | 10.1155/2011/607069 |
| URL الوصول: | https://doaj.org/article/8754fd26fdfa42169dae78309e45b463 |
| رقم الانضمام: | edsdoj.8754fd26fdfa42169dae78309e45b463 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09734945 20909810 |
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| DOI: | 10.1155/2011/607069 |