التفاصيل البيبلوغرافية
| العنوان: |
A cross-sectional study of the association between depression and serum prostate-specific antigen (PSA) among U.S. males: national health and nutrition examination survey (NHANES), 2005–2010 |
| المؤلفون: |
Yong Huang, Yingying Wang, Huiyi Su, Yao Zhang |
| المصدر: |
BMC Psychiatry, Vol 24, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Psychiatry |
| مصطلحات موضوعية: |
Depression, Patient health questionnaire-9 (PHQ-9), Prostate-specific antigen (PSA), Cross-sectional, National Health and Nutrition Examination Survey (NHANES), Psychiatry, RC435-571 |
| الوصف: |
Abstract Background The association between depression and serum total prostate-specific antigen (PSA) concentrations remains unclear. To explore whether there is a relationship between depression and PSA in American males without prostate cancer (PCa), according to the National Health and Nutrition Examination Survey (NHANES) database. Methods Three biennial cycles of survey data from 2005 to 2010 were used in our study. Multivariate adjusted regression analysis, stratified analysis, trend testing, smooth curve fitting and multiple imputation (MI) were our main research methods. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9). Results The study included a total of 4185 participants. After adjusting all covariates, whether depression was used as a continuous [β = -0.038; 95% confidence interval (CI): -0.059, -0.017; P < 0.001] or categorical variable (P for trend = 0.001), especially in the mild [β = -0.239; 95% CI: -0.473, -0.006; P = 0.044)] and moderate [β = -0.499; 95% CI: -0.907, -0.092; P = 0.016)] depression groups, it was associated with a decrease in serum PSA concentrations. Smoothing curve fitting found the presence of a linear relationship, with PSA reduced by 0.038 ng/ml or 0.026 ng/ml (log-2 transformed total PSA) for each additional unit of depression score. Similar results were obtained for complete data after MI or data categorized by depressive symptoms. Conclusions Depression score is inversely correlated with serum total PSA concentrations among American men, and there is an interaction between depression and myocardial infarction. Clinical trial number Not applicable. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-244X |
| Relation: |
https://doaj.org/toc/1471-244X |
| DOI: |
10.1186/s12888-024-06302-0 |
| URL الوصول: |
https://doaj.org/article/871e5ac892a04feea16d1c2fb4f41f25 |
| رقم الانضمام: |
edsdoj.871e5ac892a04feea16d1c2fb4f41f25 |
| قاعدة البيانات: |
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