التفاصيل البيبلوغرافية
| العنوان: |
MicroRNAs as novel biomarkers and potential therapeutic options for inflammatory cardiomyopathy |
| المؤلفون: |
Ganna Aleshcheva, Christian Baumeier, Dominik Harms, C.‐Thomas Bock, Felicitas Escher, Heinz‐Peter Schultheiss |
| المصدر: |
ESC Heart Failure, Vol 10, Iss 6, Pp 3410-3418 (2023) |
| بيانات النشر: |
Wiley, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
MiRNA, Biomarker, Inflammation, Cardiomyopathy, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Abstract Aims Inflammation of the heart is a complex biological and pathophysiological response of the immune system to a variety of injuries leading to tissue damage and heart failure. MicroRNAs (miRNAs) emerge as pivotal players in the development of numerous diseases, suggesting their potential utility as biomarkers for inflammation and as viable candidates for therapeutic interventions. The primary aim of this investigation was to pinpoint and assess particular miRNAs in individuals afflicted by virus‐negative inflammatory dilated cardiomyopathy (DCMi). Methods and results The study involved the analysis of 152 serum samples sourced from patients diagnosed with unexplained heart failure through endomyocardial biopsy. Among these samples, 38 belonged to DCMi patients, 24 to DCM patients, 44 to patients displaying inflammation alongside diverse viral infections, and 46 to patients solely affected by viral infections without concurrent inflammation. Additionally, serum samples from 10 healthy donors were included. The expression levels of 754 distinct miRNAs were evaluated using TaqMan OpenArray. MiR‐1, miR‐23, miR‐142‐5p, miR‐155, miR‐193, and miR‐195 exhibited exclusive down‐regulation solely in DCMi patients (P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.14523 |
| URL الوصول: |
https://doaj.org/article/8710aca09e4b4d6192d2a0bd0e5c8911 |
| رقم الانضمام: |
edsdoj.8710aca09e4b4d6192d2a0bd0e5c8911 |
| قاعدة البيانات: |
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