التفاصيل البيبلوغرافية
| العنوان: |
Lipoteichoic acids influence cell shape and bacterial division of Streptococcus suis serotype 2, but play a limited role in the pathogenesis of the infection |
| المؤلفون: |
Servane Payen, Marie-Christine Giroux, Nicolas Gisch, Ursula Schombel, Nahuel Fittipaldi, Mariela Segura, Marcelo Gottschalk |
| المصدر: |
Veterinary Research, Vol 55, Iss 1, Pp 1-14 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Veterinary medicine |
| مصطلحات موضوعية: |
Streptococcus suis, lipoteichoic acids, cell defect, pathogenesis, cell adhesion and invasion, cytokines, Veterinary medicine, SF600-1100 |
| الوصف: |
Abstract Streptococcus suis serotype 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans, responsible for substantial economic losses to the swine industry worldwide. The pathogenesis of infection and the role of bacterial cell wall components in virulence have not been fully elucidated. Lipoproteins, peptidoglycan, as well as lipoteichoic acids (LTA) have all been proposed to contribute to virulence. In the present study, the role of the LTA in the pathogenesis of the infection was evaluated through the characterisation of a mutant of the S. suis serotype 2 strain P1/7 lacking the LtaS enzyme, which mediates the polymerization of the LTA poly-glycerolphosphate chain. The ltaS mutant was confirmed to completely lack LTA and displayed significant morphological defects. Although the bacterial growth of this mutant was not affected, further results showed that LTA is involved in maintaining S. suis bacterial fitness. However, its role in the pathogenesis of the infection appears limited. Indeed, LTA presence reduces self-agglutination, biofilm formation and even dendritic cell activation, which are important aspects of the pathogenesis of the infection caused by S. suis. In addition, it does not seem to play a critical role in virulence using a systemic mouse model of infection. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1297-9716 |
| Relation: |
https://doaj.org/toc/1297-9716 |
| DOI: |
10.1186/s13567-024-01287-w |
| URL الوصول: |
https://doaj.org/article/86a0d1e0177b4839925ee71488dee477 |
| رقم الانضمام: |
edsdoj.86a0d1e0177b4839925ee71488dee477 |
| قاعدة البيانات: |
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