Academic Journal
Detection of active human cytomegalovirus in patients with multiple myeloma
| العنوان: | Detection of active human cytomegalovirus in patients with multiple myeloma |
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| المؤلفون: | Aya Atheer Al-Douri, Shatha Farouk Abdullah, Ali Mohammed Jawad Al-Mothaffar |
| المصدر: | Iraqi Journal of Hematology, Vol 13, Iss 1, Pp 101-105 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | human cytomegalovirus, multiple myeloma, real-time polymerase chain reaction, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | BACKGROUND: Human cytomegalovirus (HCMV) infection is ubiquitous and successfully reactivated in patients with immune dysfunction as in patient with multiple myeloma (MM), causing a wide range of life-threatening diseases. Early detection of HCMV and significant advances in MM management has amended patient outcomes and prolonged survival rates. OBJECTIVES: The aim of the study was to estimate the frequency of active HCMV in MM patients. MATERIALS AND METHODS: This is a case–control study involved 50 MM patients attending Hematology Center, Baghdad Teaching Hospital; 25 of them were newly diagnosed and 25 on treatment compared to 50 of apparently healthy control. HCMV-viral load was measured using a real-time polymerase chain reaction (RT-PCR). RESULTS: Active HCMV was detected in 8 patients out of 50 (16%); 6/25 (24%) in newly diagnosed and 2/25 (8%) on treatment and had autologous bone marrow transplant with mean ± standard deviation of 910 × 1010 ± 210 × 1010, and 32,000 × 1010 ± 1500 × 1010 IU/mL, respectively. HCMV viremia is equally detected in both remission and relapsed cases. CONCLUSION: RT-PCR detected a significant number of MM patients infected by cytomegalovirus compared to healthy individuals. Further studies are needed to verify if this finding has a relation to etiology or disease progression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2072-8069 2543-2702 |
| Relation: | https://journals.lww.com/10.4103/ijh.ijh_5_24; https://doaj.org/toc/2072-8069; https://doaj.org/toc/2543-2702 |
| DOI: | 10.4103/ijh.ijh_5_24 |
| URL الوصول: | https://doaj.org/article/e866d347241a40da944683bee60a3926 |
| رقم الانضمام: | edsdoj.866d347241a40da944683bee60a3926 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20728069 25432702 |
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| DOI: | 10.4103/ijh.ijh_5_24 |