التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of Heterogeneous Nuclear Ribonucleoprotein D Expression as a Diagnostic Marker for Oral Squamous Cell Carcinoma |
| المؤلفون: |
Vikas Kumar, Moien Rasheed Lone, Anurag Kumar, Vinnyfred Vincent, Himani Thakkar, Deepika Mishra, Shyam S. Chauhan |
| المصدر: |
Diagnostics, Vol 12, Iss 6, p 1332 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
hnRNPD, p40, diagnostic marker, oral cancer, Medicine (General), R5-920 |
| الوصف: |
The heterogeneous nuclear ribonucleoprotein D (hnRNPD) serves as a prognostic marker for oral squamous cell carcinoma (OSCC). We evaluated the diagnostic potential of hnRNPD to differentiate between OSCC and normal mucosa. Immunohistochemistry for hnRNPD and a routinely used diagnostic marker deltaNp63 (p40) was performed in 32 normal mucosae and 46 OSCC specimens. Subsequently, receiver-operating characteristic analysis was performed to evaluate the diagnostic potential of hnRNPD in comparison to that of p40. Immunostaining for p40 and hnRNPD was observed in 39 (84.78%) and 38 (82.60%) cases, respectively, in OSCC specimens. The poorly differentiated squamous cell carcinoma displayed 100% (eight cases) immunoreactivity for hnRNPD as compared to 87.5% (seven cases) for p40. Nuclear staining of p40 and hnRNPD was observed in all OSCC specimens. p40 staining was restricted to basal cells, whereas both basal and para-basal cells displayed hnRNPD staining in OSCC specimens. Areas under the curve for p40 and hnRNPD were 0.86 and 0.87, respectively. p40 and hnRNPD showed equal sensitivities (80.95%). However, hnRNPD displayed marginally higher (88.23%) specificity for tumor cells as compared to that of p40 (85.29%). Conclusion: In addition to being a well-established prognostic marker, hnRNPD can serve as a diagnostic marker for OSCC. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2075-4418 |
| Relation: |
https://www.mdpi.com/2075-4418/12/6/1332; https://doaj.org/toc/2075-4418 |
| DOI: |
10.3390/diagnostics12061332 |
| URL الوصول: |
https://doaj.org/article/aa860b894dbf4c89baa1749fa79c97fb |
| رقم الانضمام: |
edsdoj.860b894dbf4c89baa1749fa79c97fb |
| قاعدة البيانات: |
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