Academic Journal
Tuberculosis patients with diabetes co-morbidity experience reduced Mycobacterium tuberculosis complex clearance
| العنوان: | Tuberculosis patients with diabetes co-morbidity experience reduced Mycobacterium tuberculosis complex clearance |
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| المؤلفون: | Emelia Konadu Danso, Prince Asare, Stephen Osei-Wusu, Phillip Tetteh, Amanda Yaa Tetteh, Augustine Asare Boadu, Ivy Naa Koshie Lamptey, Augustina Angelina Sylverken, Kwasi Obiri-Danso, Jane Afriyie Mensah, Abraham Adjei, Dorothy Yeboah-Manu |
| المصدر: | Heliyon, Vol 10, Iss 15, Pp e35670- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Tuberculosis, Diabetes, Treatment monitoring, TB-Molecular bacterial load assay, Bacterial clearance, And bacteria load, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Objective: This study aimed to investigate the impact of diabetes mellitus (DM) on tuberculosis (TB) treatment response using bacterial clearance as a surrogate marker. Method: We compared smear microscopy, culture, and tuberculosis molecular bacterial load assay (TB-MBLA) for treatment monitoring. Following that, bacterial clearance was longitudinally monitored among TB-only (TB without DM) and TB-diabetes (TBDM) patients using TB-MBLA. Results: Ninety-three participants, including 59 TB-only and 34 TBDM patients, were enrolled. TB-only patients exhibited higher upper zone infiltrations (32/35 vs 16/22, p = 0.059) suggesting a trend towards significance, and significantly more cavitation in the same zone (16/18 vs 7/13, p = 0.028). There was a high proportion of Mycobacterium africanum (Maf) among the TBDM cohort (p = 0.0044).At baseline, TB-only patients exhibited a higher average bacterial burden (4.49 logeCFU/mL) compared to the TBDM group (3.91 logeCFU/mL) (p = 0.042). The bacterial load in the TB-only group decreased significantly during treatment but the TBDM group experienced delayed clearance throughout the intensive phase of anti-TB treatment even at day 56 (p = 0.028). The TB-only group demonstrated a shorter median time to TB-MBLA conversion to negative (57 days) compared to the TBDM group (62 days) (p = 0.022). Conclusion: These findings underscore the urgent call for understanding the interplay between diabetes and TB, emphasizing the need for tailored interventions in optimizing TB care for individuals comorbid with diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240584402411701X; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e35670 |
| URL الوصول: | https://doaj.org/article/85f9dc27cba448fdac6bb58af09f8773 |
| رقم الانضمام: | edsdoj.85f9dc27cba448fdac6bb58af09f8773 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e35670 |