التفاصيل البيبلوغرافية
| العنوان: |
The association between thyroid function and insulin resistance as measured by the metabolic score for insulin resistance (METS-IR): insights from NHANES 2007–2012 |
| المؤلفون: |
Farima Safari, Ali Nabavizadeh, Hossein Molavi Vardanjani |
| المصدر: |
BMC Endocrine Disorders, Vol 24, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: |
Thyroid function, Insulin resistance, METS-IR, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: |
Abstract Background Altered thyroid function has been linked to insulin resistance (IR), but its relationship with the Metabolic Score for Insulin Resistance (METS-IR), a novel non-insulin-based index of IR, remains unclear. This study aimed to investigate the association between thyroid function status and METS-IR in a U.S. population. Methods This cross-sectional study utilized data from 6,507 adults (aged ≥ 20 years) participating in the National Health and Nutrition Examination Survey from 2007 to 2012. Thyroid function status was categorized into five groups based on thyroid-stimulating hormone and free thyroxine levels. METS-IR was calculated from measures of fasting glucose, triglycerides, high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI). Multivariate regression analyzed the relationship between thyroid status and METS-IR after adjusting for potential confounders. Results Higher thyroid-stimulating hormone levels were positively associated with METS-IR (β = 0.003, 95% CI 0.001–0.004, p = 0.021). Subclinical hypothyroidism in males and subclinical hyperthyroidism in females showed significant correlations with higher METS-IR. Thyroid peroxidase antibodies (TPO Ab) positivity strengthened the association between overt hypothyroidism and METS-IR. Conclusions This study demonstrates significant associations between thyroid function status, particularly subclinical thyroid dysfunction, and insulin resistance as measured by METS-IR in a U.S. population. Thyroid status may serve as an early marker of insulin resistance risk. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1472-6823 |
| Relation: |
https://doaj.org/toc/1472-6823 |
| DOI: |
10.1186/s12902-024-01779-y |
| URL الوصول: |
https://doaj.org/article/85dc1d35fd984594b751e4da214d90d9 |
| رقم الانضمام: |
edsdoj.85dc1d35fd984594b751e4da214d90d9 |
| قاعدة البيانات: |
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