التفاصيل البيبلوغرافية
| العنوان: |
Risk factors for death associated with severe influenza in children and the impact of the COVID-19 pandemic on clinical characteristics |
| المؤلفون: |
Qian Hu, Wen Liang, Qiuwei Yi, Yuejie Zheng, Wenjian Wang, Yuhui Wu |
| المصدر: |
Frontiers in Pediatrics, Vol 11 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Pediatrics |
| مصطلحات موضوعية: |
influenza virus, ANE, children, ARDS, D-dimer, Pediatrics, RJ1-570 |
| الوصف: |
BackgroundTo summarize the clinical features of severe influenza in children and the high-risk factors for influenza-related deaths and to raise awareness among pediatricians.MethodsA retrospective study of clinical manifestations, laboratory tests, and diagnosis and treatment of 243 children with severe influenza admitted to Shenzhen Children's Hospital from January 2009 to December 2022 was conducted. Univariate logistic regression analysis and Boruta analysis were also performed to identify potentially critical clinical characteristics associated with death, and clinically significant were used in further multivariate logistic regression analysis. Subject receiver operating characteristic (ROC) curves were applied to assess the efficacy of death-related independent risk factors to predict death from severe influenza.ResultsThere were 169 male and 74 female patients with severe influenza, with a median age of 3 years and 2 months and 77.4% of patients under six. There were 46 cases (18.9%) in the death group. The most common pathogen was Influenza A virus (IAV) (81.5%). The most common complication in the death group was influenza-associated acute necrotizing encephalopathy (ANE [52.2%]). Severe influenza in children decreased significantly during the COVID-19 pandemic, with a median age of 5 years, a high predominance of neurological symptoms such as ANE (P = 0.001), and the most common pathogen being H3N2 (P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-2360 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fped.2023.1249058/full; https://doaj.org/toc/2296-2360 |
| DOI: |
10.3389/fped.2023.1249058 |
| URL الوصول: |
https://doaj.org/article/85ac2b5a69754e2eadb7d493aff1264e |
| رقم الانضمام: |
edsdoj.85ac2b5a69754e2eadb7d493aff1264e |
| قاعدة البيانات: |
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