Academic Journal
The roles of sodium and volume overload on hypertension in chronic kidney disease
| العنوان: | The roles of sodium and volume overload on hypertension in chronic kidney disease |
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| المؤلفون: | Jinho Shin, Chang Hwa Lee |
| المصدر: | Kidney Research and Clinical Practice, Vol 40, Iss 4, Pp 542-554 (2021) |
| بيانات النشر: | The Korean Society of Nephrology, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Internal medicine LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | antihypertensive medication, chronic kidney disease, diuretics, hemodialysis, hypertension, renin-angiotensin system, sodium, Internal medicine, RC31-1245, Specialties of internal medicine, RC581-951 |
| الوصف: | Chronic kidney disease (CKD) is associated with increased risk of cardiovascular (CV) events, and the disease burden is rising rapidly. An important contributor to CV events and CKD progression is high blood pressure (BP). The main mechanisms of hypertension in early and advanced CKD are renin-angiotensin system activation and volume overload, respectively. Sodium retention is well known as a factor for high BP in CKD. However, a BP increase in response to total body sodium or volume overload can be limited by neurohormonal modulation. Recent clinical trial data favoring intensive BP lowering in CKD imply that the balance between volume and neurohormonal control could be revisited with respect to the safety and efficacy of strict volume control when using antihypertensive medications. In hemodialysis patients, the role of more liberal use of antihypertensive medications with the concept of functional dry weight for intensive BP control must be studied. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2211-9132 2211-9140 |
| Relation: | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-800.pdf; https://doaj.org/toc/2211-9132; https://doaj.org/toc/2211-9140 |
| DOI: | 10.23876/j.krcp.21.800 |
| URL الوصول: | https://doaj.org/article/85a4c0aa2bf44689b7b39dcc9c65ece0 |
| رقم الانضمام: | edsdoj.85a4c0aa2bf44689b7b39dcc9c65ece0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22119132 22119140 |
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| DOI: | 10.23876/j.krcp.21.800 |