Academic Journal
NF-κB-Mediated Regulation of Osteoclastogenesis
| العنوان: | NF-κB-Mediated Regulation of Osteoclastogenesis |
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| المؤلفون: | Brendan F. Boyce, Yan Xiu, Jinbo Li, Lianping Xing, Zhenqiang Yao |
| المصدر: | Endocrinology and Metabolism, Vol 30, Iss 1, Pp 35-44 (2015) |
| بيانات النشر: | Korean Endocrine Society, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | NF-kappa B, Osteoclasts, RANK ligand, Tumor necrosis factor, TNF receptor-associated factor 3, NF-kappa B kinase, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding of the molecular mechanisms regulating osteoclast formation and functions have been made in the past 20 years since the discovery that their formation requires nuclear factor-kappa B (NF-κB) signaling and that this is activated in response to the essential osteoclastogenic cytokine, receptor activator of NF-κB ligand (RANKL), which also controls osteoclast activation to resorb (degrade) bone. These studies have revealed that RANKL and some pro-inflammatory cytokines, including tumor necrosis factor, activate NF-κB and downstream signaling, including c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), and inhibition of repressors of NFATc1 signaling, to positively regulate osteoclast formation and functions. However, these cytokines also activate NF-κB signaling that can limit osteoclast formation through the NF-κB signaling proteins, TRAF3 and p100, and the suppressors of c-Fos/NFATc1 signaling, IRF8, and RBP-J. This paper reviews current understanding of how NF-κB signaling is involved in the positive and negative regulation of cytokine-mediated osteoclast formation and activation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2093-596X 2093-5978 |
| Relation: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-30-35.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978 |
| DOI: | 10.3803/EnM.2015.30.1.35 |
| URL الوصول: | https://doaj.org/article/cd85988a34694c718ef4d47927f0db3a |
| رقم الانضمام: | edsdoj.85988a34694c718ef4d47927f0db3a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2093596X 20935978 |
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| DOI: | 10.3803/EnM.2015.30.1.35 |