التفاصيل البيبلوغرافية
| العنوان: |
Structural characterization and anti-inflammatory activity of a novel polysaccharide from Paeonia lactiflora Pall |
| المؤلفون: |
Pei-Pei Li, Xiang-Ming Jiang, Jin-Yang Shi, Wei Zhang, Yang-Fei Ding, Song-Zi Xie, De-Ling Wu |
| المصدر: |
Journal of Functional Foods, Vol 120, Iss , Pp 106392- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
Paeonia lactiflora Pall., Polysaccharides, Anti-inflammatory activity, Structural characterization, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
A novel homogeneous polysaccharide, designated as PLPN-2, was screened from the dried root of Paeonia lactiflora Pall. using an activity-oriented approach, demonstrating remarkable anti-inflammatory properties. Structural analysis revealed that PLPN-2 is an α-glucan comprising an α-(1 → 4)-glucan backbone with α-Glcp-(1→/α-Glcp-(1 → 6)-β-Glcp-(1→ linked to the backbone at C-6. PLPN-2 exhibited efficacy in alleviating inflammatory symptoms associated with DSS-induced colitis in mice and inhibiting the release of pro-inflammatory elements including IL-6, TNF-α, IL-1β from RAW264.7 macrophages promoted by LPS. Moreover, PLPN-2 demonstrated ability to impede the nuclear translocation of the p65 protein and reduce the phosphorylation levels of JNK, ERK1/2, p38, p65, and IκBα. The findings suggest that PLPN-2 exhibits potential as an anti-inflammatory agent through the inhibition of the MAPK and NF-κB signaling pathways. Therefore, PLPN-2 shows promising prospects as a functional agent for relieving inflammation-related disorders. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464624003943; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2024.106392 |
| URL الوصول: |
https://doaj.org/article/ac8586d7ec38468ba0274161c70b5eba |
| رقم الانضمام: |
edsdoj.8586d7ec38468ba0274161c70b5eba |
| قاعدة البيانات: |
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