Academic Journal
Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia
| العنوان: | Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia |
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| المؤلفون: | Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M Canuso |
| المصدر: | Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 5, Pp 949-958 (2008) |
| بيانات النشر: | Dove Medical Press, 2008. |
| سنة النشر: | 2008 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Ibrahim Turkoz, Cynthia A Bossie, Bryan Dirks, Carla M CanusoOrtho-McNeil Janssen Scientific Affairs, LLC, Titusville, NJ, USAAbstract: Direct and indirect effects of the new psychotropic paliperidone extended-release (paliperidone ER) tablets on negative symptom improvement in schizophrenia were investigated using path analysis. A post hoc analysis of pooled data from three 6-week, double-blind, placebo-controlled studies of paliperidone ER in patients experiencing acute exacerbation was conducted. Regression analysis explored relationships between baseline/study characteristics and negative symptoms. Change in Positive and Negative Syndrome Scale (PANSS) negative factor score at endpoint was the dependent variable; explanatory variables included demographic and clinical characteristics. Path analysis determined direct and indirect effects of treatment on negative symptom change. Indirect mediators of negative symptom change in the model included changes in positive symptoms, anxiety/depression symptoms and movement disorders. Path analysis indicated that up to 33% of negative symptom improvement was a direct treatment effect. Indirect effects on negative symptoms were mediated through changes in positive symptoms (51%) and anxiety/depression symptoms (18%), whereas changes in movement disorders had a 2.1% inverse effect. Path analysis indicated that paliperidone ER has a direct effect on negative symptoms. Negative symptom improvement also was indirectly mediated via changes in positive and depressive symptoms.Keywords: antipsychotic, paliperidone ER, path analysis, psychotropic, schizophrenia |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1176-6328 1178-2021 |
| Relation: | http://www.dovepress.com/direct-and-indirect-effects-of-paliperidone-extended-release-tablets-o-a2012; https://doaj.org/toc/1176-6328; https://doaj.org/toc/1178-2021 |
| URL الوصول: | https://doaj.org/article/a85737ed2de249969bd1778a236c12c1 |
| رقم الانضمام: | edsdoj.85737ed2de249969bd1778a236c12c1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11766328 11782021 |
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