Academic Journal
Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space
| العنوان: | Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space |
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| المؤلفون: | Tae-Geun Yu, Jeong Seok Cha, Gijeong Kim, Yoo-Kyoung Sohn, Youngki Yoo, Uijin Kim, Ji-Joon Song, Hyun-Soo Cho, Hak-Sung Kim |
| المصدر: | Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Inflammasomes are multi-protein complexes and play a crucial role in host defense against pathogens. Downstream inflammatory responses through inflammasomes are known to be related to the oligomerization degree of ASC specks, but the detailed mechanism still remains unexplored. Here, we demonstrate that oligomerization degrees of ASC specks regulate the caspase-1 activation in the extracellular space. A protein binder specific for a pyrin domain (PYD) of ASC (ASCPYD) was developed, and structural analysis revealed that the protein binder effectively inhibits the interaction between PYDs, disassembling ASC specks into low oligomeric states. ASC specks with a low oligomerization degree were shown to enhance the activation of caspase-1 by recruiting and processing more premature caspase-1 through interactions between CARD of caspase-1 (caspase-1CARD) and CARD of ASC (ASCCARD). These findings can provide insight into controlling the inflammasome-mediated inflammatory process as well as the development of inflammasome-targeting drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2058-7716 |
| Relation: | https://doaj.org/toc/2058-7716 |
| DOI: | 10.1038/s41420-023-01438-6 |
| URL الوصول: | https://doaj.org/article/856e837c4d0b4415a2bd4508df583a36 |
| رقم الانضمام: | edsdoj.856e837c4d0b4415a2bd4508df583a36 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20587716 |
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| DOI: | 10.1038/s41420-023-01438-6 |