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Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

التفاصيل البيبلوغرافية
العنوان: Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi
المؤلفون: Edgar M Medina, Jonathan J Turner, Raluca Gordân, Jan M Skotheim, Nicolas E Buchler
المصدر: eLife, Vol 5 (2016)
بيانات النشر: eLife Sciences Publications Ltd, 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: cell cycle, evolution, fungi, chytrid, virus, horizontal gene transfer, Medicine, Science, Biology (General), QH301-705.5
الوصف: Although cell cycle control is an ancient, conserved, and essential process, some core animal and fungal cell cycle regulators share no more sequence identity than non-homologous proteins. Here, we show that evolution along the fungal lineage was punctuated by the early acquisition and entrainment of the SBF transcription factor through horizontal gene transfer. Cell cycle evolution in the fungal ancestor then proceeded through a hybrid network containing both SBF and its ancestral animal counterpart E2F, which is still maintained in many basal fungi. We hypothesize that a virally-derived SBF may have initially hijacked cell cycle control by activating transcription via the cis-regulatory elements targeted by the ancestral cell cycle regulator E2F, much like extant viral oncogenes. Consistent with this hypothesis, we show that SBF can regulate promoters with E2F binding sites in budding yeast.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/09492; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.09492
URL الوصول: https://doaj.org/article/8537725b9a504f48862d717c34ecf96c
رقم الانضمام: edsdoj.8537725b9a504f48862d717c34ecf96c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.09492