التفاصيل البيبلوغرافية
| العنوان: |
Low-intensity pulsed ultrasound promotes periodontal regeneration in a beagle model of furcation involvement |
| المؤلفون: |
Yue Wang, Qingyue Xiao, Wenjie Zhong, Chuangwei Zhang, Yuanyuan Yin, Xiang Gao, Jinlin Song |
| المصدر: |
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biotechnology |
| مصطلحات موضوعية: |
furcation involvement, low-intensity pulsed ultrasound, inflammation, regeneration, beagle dog, Biotechnology, TP248.13-248.65 |
| الوصف: |
Objective: To evaluate the regeneration potential of periodontitis tissue treated by low-intensity pulsed ultrasound (LIPUS) combined with the guided tissue regeneration (GTR) technique in a beagle model of furcation involvement (FI).Background: Achieving predictable regeneration remains a clinical challenge for periodontitis tissue due to the compromised regenerative potential caused by chronic inflammation stimulation. LIPUS, an FDA-approved therapy for long bone fracture and non-unions, has been demonstrated effective in the in vitro attenuation of inflammation-induced dysfunction of periodontal ligament stem cells (PDLSCs), the key cells contributing to periodontal regeneration. However, the in vivo effect of LIPUS on periodontitis tissue is rarely reported.Methods: A beagle model of FI was established, and the experimental teeth were randomly assigned into three groups: control group, GTR group, and GTR+LIPUS group. Radiographic examinations were performed, and clinical periodontal parameters were recorded to reflect the periodontal condition of different groups. Histological analyses using H&E and Masson’s staining were conducted to evaluate the periodontal tissue regeneration.Results: LIPUS could enhance new periodontal bone formation and bone matrix maturity in FI after GTR treatment. Moreover, clinical assessment and histomorphometric analyses revealed less inflammatory infiltration and superior vascularization within bone grafts in the LIPUS treatment group, indicating the anti-inflammatory and pro-angiogenic effects of LIPUS in FI.Conclusion: Our investigation on a large animal model demonstrated that LIPUS is a promising adjunctive approach for the regeneration of periodontitis tissue, paving a new avenue for LIPUS application in the field of periodontal regenerative medicine. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-4185 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fbioe.2022.961898/full; https://doaj.org/toc/2296-4185 |
| DOI: |
10.3389/fbioe.2022.961898 |
| URL الوصول: |
https://doaj.org/article/84eda2fef4744dd99a7d247cf1872521 |
| رقم الانضمام: |
edsdoj.84eda2fef4744dd99a7d247cf1872521 |
| قاعدة البيانات: |
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