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Ratio of Th17/Treg and Disease Activity in Systemic Lupus Erythematosus

التفاصيل البيبلوغرافية
العنوان: Ratio of Th17/Treg and Disease Activity in Systemic Lupus Erythematosus
المؤلفون: Yuliasih Yuliasih, Lita Diah Rahmawati, Rizki Maulidya Putri
المصدر: Caspian Journal of Internal Medicine, Vol 10, Iss 1, Pp 65-72 (2019)
بيانات النشر: Babol University of Medical Sciences, 2019.
سنة النشر: 2019
المجموعة: LCC:Internal medicine
مصطلحات موضوعية: Systemic Lupus Erythematosus, disease activity, Th17, Treg, Th17/Treg ratio, Internal medicine, RC31-1245
الوصف: Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by T-cells imbalance. There are ongoing controversies about the role of specific T-helper cell subsets and their cytokines. The study aimed to confirm the disturbance of Th17/Treg ratio in SLE patients. Methods: Subjects were SLE patients who met the American College of Rheumatology 1997 criteria. Disease activity assessment was measured by SLAM index. Th17 and Treg level was measured by flow cytometry. Th17 level was evaluated as CD4+L17 whilst Treg as CD4+Foxp3+. Final result is stated as Th17/Treg ratio. Results: Thirty female subjects with active SLE had mean SLAM Score of 29.3±3.88, C3 level 25.2 (6-59.5), C4 level 15.25 (5-54.3), ESR 62.1±37.85, CRP 30.16±59.45, and anti-dsDNA 155.32±186.10. Higher Th17 level was found in SLE patients compared to healthy subjects (30.09 pg/ml vs 13.01pg/ml; 12.60% vs 0.91%). However, it did not correlate to disease activity (p>0.05; r=-0.28). Regarding Treg level, there was no significant difference between active SLE and healthy subjects (12.85 vs 11.05 pg/ml; 9.57% vs 2.05%). Treg level negatively correlated to SLE disease activity (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2008-6164
2008-6172
Relation: http://caspjim.com/browse.php?a_code=A-10-1150-1&slc_lang=en&sid=1; https://doaj.org/toc/2008-6164; https://doaj.org/toc/2008-6172
URL الوصول: https://doaj.org/article/849e4336c37c47b6a6bfab10e6fbcc66
رقم الانضمام: edsdoj.849e4336c37c47b6a6bfab10e6fbcc66
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20086164
20086172