Academic Journal
Effectiveness of test-and-treat model with direct-acting antiviral for hepatitis C virus infection in migrants: a prospective interventional study in Italy
| العنوان: | Effectiveness of test-and-treat model with direct-acting antiviral for hepatitis C virus infection in migrants: a prospective interventional study in Italy |
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| المؤلفون: | Nicola Coppola, Loredana Alessio, Stefania De Pascalis, Margherita Macera, Giovanni Di Caprio, Vincenzo Messina, Lorenzo Onorato, Carmine Minichini, Maria Stanzione, Gianfranca Stornaiuolo, Mario Starace, Caterina Monari, Federica Calò, Caterina Sagnelli, Mariantonietta Pisaturo |
| المصدر: | Infectious Diseases of Poverty, Vol 13, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| مصطلحات موضوعية: | HCV, Burden, Elimination, Migrant, Italy, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Background Migrants, mainly undocumented and low-income refugees, are at high risk of hepatitis C virus (HCV) infection, but are a difficult-to-reach and to-treat population. The aim of the study was to evaluate the effectiveness of a test and treat model with direct-acting antiviral for HCV infection in these migrants coming from low-income and living in southern Italy. Methods A prospective, multicenter, collaborative study based on a four-phase-program (educational counseling, screening, linkage-to-care and treatment) was designed in southern Italy; the study started in June 2018, was stopped in February 2020 because of the outbreak of SARS-CoV2 infection in Italy and was resumed in February 2021 until November 2021. After educational counseling on infectious diseases that are transmitted through blood or sexually pseudonymized HCV screening was offered to all undocumented migrants and low-income refugees observed at one of the 1st level clinical centers. The HCV-RNA-positive subjects were referred to one of the 3rd level units of Infectious Diseases (ID) and treated with a 12-week course of sofosbuvir-velpatasvir and observed for 12 weeks after the end of direct antiviral agents (DAA) treatment. Statistical analysis For the descriptive analysis, the categorical variables were reported as absolute numbers and relative frequencies. Continuous variables were summarized as mean and standard deviation (SD) if normally distributed, or as a median and interquartile range (IQR) if not normally distributed. We used Pearson chi-square or Fisher’s exact test for categorical variables and Student’s t test or Mann–Whitney test for continuous variables. A P value |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2049-9957 66544319 |
| Relation: | https://doaj.org/toc/2049-9957 |
| DOI: | 10.1186/s40249-024-01200-9 |
| URL الوصول: | https://doaj.org/article/8485628b66544319bd096533a46b1844 |
| رقم الانضمام: | edsdoj.8485628b66544319bd096533a46b1844 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20499957 66544319 |
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| DOI: | 10.1186/s40249-024-01200-9 |