التفاصيل البيبلوغرافية
| العنوان: |
Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients |
| المؤلفون: |
Yufei Mo, Kelvin Kai-Wang To, Runhong Zhou, Li Liu, Tianyu Cao, Haode Huang, Zhenglong Du, Chun Yu Hubert Lim, Lok-Yan Yim, Tsz-Yat Luk, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Owen Tak-Yin Tsang, Anthony Raymond Tam, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Zhiwei Chen |
| المصدر: |
Frontiers in Immunology, Vol 12 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
mitochondrial dysfunction (MD), T-cell functionality, memory T cell, SARS-CoV-2, COVID-19, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in rapid T lymphocytopenia and functional impairment of T cells. The underlying mechanism, however, remains incompletely understood. In this study, we focused on characterizing the phenotype and kinetics of T-cell subsets with mitochondrial dysfunction (MD) by multicolor flow cytometry and investigating the association between MD and T-cell functionality. While 73.9% of study subjects displayed clinical lymphocytopenia upon hospital admission, a significant reduction of CD4 or CD8 T-cell frequency was found in all asymptomatic, symptomatic, and convalescent cases. CD4 and CD8 T cells with increased MD were found in both asymptomatic and symptomatic patients within the first week of symptom onset. Lower proportion of memory CD8 T cell with MD was found in severe patients than in mild ones at the stage of disease progression. Critically, the frequency of T cells with MD in symptomatic patients was preferentially associated with CD4 T-cell loss and CD8 T-cell hyperactivation, respectively. Patients bearing effector memory CD4 and CD8 T cells with the phenotype of high MD exhibited poorer T-cell responses upon either phorbol 12-myristate-13-acetate (PMA)/ionomycin or SARS-CoV-2 peptide stimulation than those with low MD. Our findings demonstrated an MD-associated mechanism underlying SARS-CoV-2-induced T lymphocytopenia and functional impairment during the acute phase of infection. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.799896/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2021.799896 |
| URL الوصول: |
https://doaj.org/article/847b178133554300bd35131d3ec55877 |
| رقم الانضمام: |
edsdoj.847b178133554300bd35131d3ec55877 |
| قاعدة البيانات: |
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