Academic Journal
Carcinogenic effect of arsenic in digestive cancers: a systematic review
| العنوان: | Carcinogenic effect of arsenic in digestive cancers: a systematic review |
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| المؤلفون: | Sophie Kasmi, Laureline Moser, Stéphanie Gonvers, Olivier Dormond, Nicolas Demartines, Ismail Labgaa |
| المصدر: | Environmental Health, Vol 22, Iss 1, Pp 1-11 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Industrial medicine. Industrial hygiene LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Oncogenic, Toxicants, Heavy metals, Carcinogenesis, Prevention, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Background The carcinogenic effect of arsenic (As) has been documented in lung, bladder and skin cancers but remains unclear for digestive cancers, although metabolic pathways of As and recent data suggest that it may be an important determinant in these malignancies as well. Objective This study aimed to systematically review the available literature investigating the potential association between As and digestive cancers. Methods An extensive search was conducted in Medline Ovid SP, Cochrane, PubMed, Embase.com, Cochrane Library Wiley, Web of Science and Google Scholar. Studies providing original data in humans, with As measurement and analysis of association with digestive cancers including esogastric cancers (esophagus and stomach), hepato-pancreatico-biliary (HPB) cancers (including biliary tract, liver and pancreas) and colorectal cancers were eligible. Results A total of 35 studies were identified, 17 ecological, 13 case–control and 5 cohort studies. Associations between As and digestive cancers were reported for both risks of incidence and cancer-related mortality. Overall, 43% (3/7) and 48% (10/21) studies highlighted an association between As and the incidence or the mortality of digestive cancers, respectively. Conclusions A substantial proportion of studies exploring the potential link between As and digestive cancers suggested an association, particularly in HPB malignancies. These findings emphasize the need to further investigate this topic with dedicated and high-quality studies, as it may have an important impact, including for prevention strategies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1476-069X |
| Relation: | https://doaj.org/toc/1476-069X |
| DOI: | 10.1186/s12940-023-00988-7 |
| URL الوصول: | https://doaj.org/article/8464619101654b3cb9682152ee72b6bb |
| رقم الانضمام: | edsdoj.8464619101654b3cb9682152ee72b6bb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1476069X |
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| DOI: | 10.1186/s12940-023-00988-7 |