التفاصيل البيبلوغرافية
| العنوان: |
Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism |
| المؤلفون: |
Payman Zamani, Elizabeth A. Proto, Neil Wilson, Hossein Fazelinia, Hua Ding, Lynn A. Spruce, Antonio Davila Jr., Thomas C. Hanff, Jeremy A. Mazurek, Stuart B. Prenner, Benoit Desjardins, Kenneth B. Margulies, Daniel P. Kelly, Zoltan Arany, Paschalis‐Thomas Doulias, John W. Elrod, Mitchell E. Allen, Shana E. McCormack, Gayatri Maria Schur, Kevin D'Aquilla, Dushyant Kumar, Deepa Thakuri, Karthik Prabhakaran, Michael C. Langham, David C. Poole, Steven H. Seeholzer, Ravinder Reddy, Harry Ischiropoulos, Julio A. Chirinos |
| المصدر: |
ESC Heart Failure, Vol 8, Iss 4, Pp 2698-2712 (2021) |
| بيانات النشر: |
Wiley, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
HFpEF, Exercise, Skeletal muscle, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Abstract Aims Skeletal muscle (SkM) abnormalities may impact exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF). We sought to quantify differences in SkM oxidative phosphorylation capacity (OxPhos), fibre composition, and the SkM proteome between HFpEF, hypertensive (HTN), and healthy participants. Methods and results Fifty‐nine subjects (20 healthy, 19 HTN, and 20 HFpEF) performed a maximal‐effort cardiopulmonary exercise test to define peak oxygen consumption (VO2, peak), ventilatory threshold (VT), and VO2 efficiency (ratio of total work performed to O2 consumed). SkM OxPhos was assessed using Creatine Chemical‐Exchange Saturation Transfer (CrCEST, n = 51), which quantifies unphosphorylated Cr, before and after plantar flexion exercise. The half‐time of Cr recovery (t1/2, Cr) was taken as a metric of in vivo SkM OxPhos. In a subset of subjects (healthy = 13, HTN = 9, and HFpEF = 12), percutaneous biopsy of the vastus lateralis was performed for myofibre typing, mitochondrial morphology, and proteomic and phosphoproteomic analysis. HFpEF subjects demonstrated lower VO2,peak, VT, and VO2 efficiency than either control group (all P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.13329 |
| URL الوصول: |
https://doaj.org/article/844dfa64ac194144b322d72abdbf2866 |
| رقم الانضمام: |
edsdoj.844dfa64ac194144b322d72abdbf2866 |
| قاعدة البيانات: |
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