التفاصيل البيبلوغرافية
| العنوان: |
The impact of qualitative [18F]FDG PET/CT in predicting clinical outcomes of post-surgical differentiated thyroid cancer patients with elevated thyroglobulin and negative radioiodine whole-body scan |
| المؤلفون: |
Le Ngoc Ha, Nguyen Thi Phuong, Mai Hong Son |
| المصدر: |
BMC Surgery, Vol 24, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Surgery |
| مصطلحات موضوعية: |
[18F]FDG PET/CT, Qualitative, Prognosis, PFS, OS, TENIS, Surgery, RD1-811 |
| الوصف: |
Abstract Background [18F]FDG PET/CT has been widely used as a diagnostic tool in detection and localization of recurrent non-avid radioiodine lesions in post-operative differentiated thyroid cancer (DTC) patients with elevated serum thyroglobulin but negative radioiodine whole-body scan (TENIS) syndrome. The aim of our study was to evaluate the role of [18F]FDG PET/CT in prediction on outcomes of these DTC patients. Methods Post-operative DTC patients with TENIS syndrome were collected in the department of nuclear medicine, Hospital 108 from 2019 to 2023. Patients underwent [18F]FDG PET/CT with standard protocol following EANM guideline for tumor imaging version 2.0. The qualitative [18F]FDG PET/CT imaging characteristics were classified into three categories: (i) negative [18F]FDG PET/CT, (ii) minimal [18F]FDG PET/CT volume of lesions, (iii) extensive [18F]FDG PET/CT volume of lesions. Progression-free survival (PFS) and overall survival (OS) were the end point of the study. The prognosis of qualitative [18F]FDG PET/CT in predicting PFS and OS was illustrated by Kaplan–Meier survival analysis. The independent factors predicting PFS and OS were determined by univariate and multivariate analysis using logistic regression. Results There were 164 consecutive patients, 51.2% female and 48.8% female. The most common histopathological type was papillary accounting for 91.5%. The median time of follow-up was 33.3 months, (range 6.57 – 82.5). There was 70 (36.6%) progressions and 12 (7.35%) deaths. Negative [18F]FDG PET/CT uptake patients had median PFS with median 57.1 months which was higher than that of minimal category (46.2 months), and extensive category (37.6 months) (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2482 |
| Relation: |
https://doaj.org/toc/1471-2482 |
| DOI: |
10.1186/s12893-024-02675-x |
| URL الوصول: |
https://doaj.org/article/83dd1f2d7550475bbbc787c94b134462 |
| رقم الانضمام: |
edsdoj.83dd1f2d7550475bbbc787c94b134462 |
| قاعدة البيانات: |
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