التفاصيل البيبلوغرافية
| العنوان: |
Omicron neutralization character in patients with breast cancer and liver cancer after the nationwide omicron outbreak |
| المؤلفون: |
Shaohua Zhang, Lili Tang, Chunmei Bao, Siyu Wang, Bo Li, Lei Huang, Hua Song, Junliang Fu, Zhe Xu, Fanping Meng, Lin Cao, Yingying Gao, Yue Yuan, Yangliu Chen, Jinhong Yuan, Chunbao Zhou, Fan Li, Lili Qin, Yingfei Guo, Chao Zhang, Jinwen Song, Xing Fan, Zefei Jiang, Fu‐Sheng Wang, Ruonan Xu |
| المصدر: |
Cancer Medicine, Vol 13, Iss 11, Pp n/a-n/a (2024) |
| بيانات النشر: |
Wiley, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
antibody, cancer patients, COVID‐19, omicron, vaccine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Background The surge in omicron variants has caused nationwide breakthrough infections in mainland China since the December 2022. In this study, we report the neutralization profiles of serum samples from the patients with breast cancer and the patients with liver cancer who had contracted subvariant breakthrough infections. Methods In this real‐world study, we enrolled 143 COVID‐19‐vaccinated (81 and 62 patients with breast and liver cancers) and 105 unvaccinated patients with cancer (58 and 47 patients with breast and liver cancers) after omicron infection. Anti‐spike receptor binding domain (RBD) IgGs and 50% pseudovirus neutralization titer (pVNT50) for the preceding (wild type), circulating omicron (BA.4‐BA.5, and BF.7), and new subvariants (XBB.1.5) were comprehensively analyzed. Results Patients with liver cancer receiving booster doses had higher levels of anti‐spike RBD IgG against circulating omicron (BA.4‐BA.5, and BF.7) and a novel subvariant (XBB.1.5) compared to patients with breast cancer after breakthrough infection. Additionally, all vaccinated patients produced higher neutralizing antibody titers against circulating omicron (BA.4‐BA.5, and BF.7) compared to unvaccinated patients. However, the unvaccinated patients produced higher neutralizing antibody against XBB.1.5 than vaccinated patients after Omicron infection, with this trend being more pronounced in breast cancer than in liver cancer patients. Moreover, we found that there was no correlation between anti‐spike RBD IgG against wildtype virus and the neutralizing antibody titer, but a positive correlation between anti‐spike RBD IgG and the neutralizing antibody against XBB.1.5 was found in unvaccinated patients. Conclusion Our study found that there may be differences in vaccine response and protective effect against COVID‐19 infection in patients with liver and breast cancer. Therefore, we recommend that COVID‐19 vaccine strategies should be optimized based on vaccine components and immunology profiles of different patients with cancer. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2045-7634 |
| Relation: |
https://doaj.org/toc/2045-7634 |
| DOI: |
10.1002/cam4.7304 |
| URL الوصول: |
https://doaj.org/article/83958743bd354ea19fec061b9fbbbd01 |
| رقم الانضمام: |
edsdoj.83958743bd354ea19fec061b9fbbbd01 |
| قاعدة البيانات: |
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