Academic Journal
Gefitinib: Combination Therapy and Complex Delivery Systems (Review)
| العنوان: | Gefitinib: Combination Therapy and Complex Delivery Systems (Review) |
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| المؤلفون: | L. L. Nikolaeva, E. V. Sanarova, A. V. Lantsova |
| المصدر: | Разработка и регистрация лекарственных средств, Vol 13, Iss 1, Pp 26-33 (2024) |
| بيانات النشر: | LLC Center of Pharmaceutical Analytics (LLC «CPHA»), 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pharmaceutical industry |
| مصطلحات موضوعية: | tyrosine kinase inhibitors, overcoming resistance, carriers, photodynamic therapy, Pharmaceutical industry, HD9665-9675 |
| الوصف: | Introduction. The search for new methods of therapy for non-small cell lung cancer (NSCLC) is an urgent task of modern science. Gefitinib is a targeted drug widely used in the treatment of NSCLC in patients with a mutation in the epidermal growth factor receptor tyrosine kinase domain. However, using of gefitinib and other drugs from the group of tyrosine kinase inhibitors is to limited by rapidly developing resistance, for this reason finding of a ways overcome drug resistance is actual part of research interests.Text. The review is devoted to the use of gefitinib in modern developments: introduction to various targeted delivery systems (liposomes, micelles, microspheres, etc.), studying it in combination with other chemotherapeutic agents, as well as in combination with photo- or thermosensitive compounds in various micro- and nanostructured complexes.Conclusion. As a result of the analysis of literature data, it was shown that, despite the fact that gefitinib is a first-generation drug, foreign and Russian researchers consider it quite promising for further use in the treatment of NSCLC. At the same time, developments are being carried out both in the field of expanding combination therapy and in the field of creating complex structures of targeted action, into which, in addition to gefitinib, photosensitizers or other compounds with photo- or thermosensitive effects are introduced. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2305-2066 2658-5049 |
| Relation: | https://www.pharmjournal.ru/jour/article/view/1717; https://doaj.org/toc/2305-2066; https://doaj.org/toc/2658-5049 |
| DOI: | 10.33380/2305-2066-2024-13-1-1615 |
| URL الوصول: | https://doaj.org/article/835e42ce8414401a85691e1b299c2abc |
| رقم الانضمام: | edsdoj.835e42ce8414401a85691e1b299c2abc |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23052066 26585049 |
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| DOI: | 10.33380/2305-2066-2024-13-1-1615 |