التفاصيل البيبلوغرافية
| العنوان: |
Shexiang Baoxin Pill, a Proprietary Multi-Constituent Chinese Medicine, Prevents Locomotor and Cognitive Impairment Caused by Brain Ischemia and Reperfusion Injury in Rats: A Potential Therapy for Neuropsychiatric Sequelae of Stroke |
| المؤلفون: |
Zong-Shi Qin, Yu Zheng, Xi-Dan Zhou, Dong-Dong Shi, Dan Cheng, Chun Shum Shek, Chang-Sen Zhan, Zhang-Jin Zhang |
| المصدر: |
Frontiers in Pharmacology, Vol 12 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: |
middle cerebral artery occlusion, locomotor ability, post stroke cognitive impairment, shexiang baoxin pill, ischemic stroke, Therapeutics. Pharmacology, RM1-950 |
| الوصف: |
Ischemic stroke is a common type of cerebrovascular event and also the leading cause of disability. Post-stroke cognitive impairment occurs frequently in stroke survivors. Shexiang Baoxin Pill (SBP) is a proprietary Chinese medicine, initially used to treat cardiovascular diseases. Herein, we aim to explore the effects of SBP on oxygen glucose deprivation and reoxygenation (OGD/R) in neuronal cells (CATH.a) and cerebral ischemia/reperfusion injury induced post-stroke cognitive impairment in middle cerebral artery occlusion (MCAO) rat model. MCAO rats received two doses of oral SBP treatment (28 or 56 mg/kg) after 1 h of operation and once daily for 2 weeks continuously. Behavioral tests, immunoblotting, and immunofluorescence were examined after 14 days. Current data suggest that SBP enhanced cell viability and downregulated apoptosis via activating the PI3K/Akt signaling pathway in CATH. a cells. Furthermore, 14 days of SBP treatment promoted the recovery of learning and locomotor function in the MCAO rats. SBP up-regulated the expression of p-Akt, p-GSK3β, as well as the expression of NMDAR1, PSD-95, and AMPAR. Also, SBP down-regulated the expression of p-CaMKII. These results indicated that long-term SBP treatment might be a potential option for cognitive impairment induced by the ischemic stroke. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1663-9812 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphar.2021.665456/full; https://doaj.org/toc/1663-9812 |
| DOI: |
10.3389/fphar.2021.665456 |
| URL الوصول: |
https://doaj.org/article/e82fd4dd2c6e48a48e3b1ccb2e4c3289 |
| رقم الانضمام: |
edsdoj.82fd4dd2c6e48a48e3b1ccb2e4c3289 |
| قاعدة البيانات: |
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