Academic Journal
In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis
| العنوان: | In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis |
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| المؤلفون: | Maxime Donadieu, Nathanael J Lee, María I Gaitán, Seung-Kwon Ha, Nicholas J Luciano, Snehashis Roy, Benjamin Ineichen, Emily C Leibovitch, Cecil C Yen, Dzung L Pham, Afonso C Silva, Mac Johnson, Steve Jacobson, Pascal Sati, Daniel S Reich |
| المصدر: | eLife, Vol 12 (2023) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | marmoset, EAE, MRI, remyelination, primate, histopathology, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Remyelination is crucial to recover from inflammatory demyelination in multiple sclerosis (MS). Investigating remyelination in vivo using magnetic resonance imaging (MRI) is difficult in MS, where collecting serial short-interval scans is challenging. Using experimental autoimmune encephalomyelitis (EAE) in common marmosets, a model of MS that recapitulates focal cerebral inflammatory demyelinating lesions, we investigated whether MRI is sensitive to, and can characterize, remyelination. In six animals followed with multisequence 7 T MRI, 31 focal lesions, predicted to be demyelinated or remyelinated based on signal intensity on proton density-weighted images, were subsequently assessed with histopathology. Remyelination occurred in four of six marmosets and 45% of lesions. Radiological-pathological comparison showed that MRI had high statistical sensitivity (100%) and specificity (90%) for detecting remyelination. This study demonstrates the prevalence of spontaneous remyelination in marmoset EAE and the ability of in vivo MRI to detect it, with implications for preclinical testing of pro-remyelinating agents. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/73786; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.73786 |
| URL الوصول: | https://doaj.org/article/82b3b20c13e342e28b70423fafd616cb |
| رقم الانضمام: | edsdoj.82b3b20c13e342e28b70423fafd616cb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.73786 |