Academic Journal
Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic
| العنوان: | Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic |
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| المؤلفون: | Renato Ribeiro-Viana, Elena Bonechi, Javier Rojo, Clara Ballerini, Giuseppina Comito, Barbara Richichi, Cristina Nativi |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1317-1324 (2014) |
| بيانات النشر: | Beilstein-Institut, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | cancer immunotherapy, DC-SIGN, DC targeting, glycodendron, GM3-lactone mimetic, multivalent glycosystems, multivalent interactions, Science, Organic chemistry, QD241-441 |
| الوصف: | Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis of the bifunctional multivalent glycodendron 5, which contains nine residues of mannose for DC targeting and one residue of an immunogenic mimetic of a carbohydrate melanoma associated antigen. The immunological assays demonstrated that the glycodendron 5 is able to induce human immature DC activation in terms of a phenotype expression of co-stimulatory molecules expression and MHCII. Furthermore, DCs activated by the glycodendron 5 stimulate T lymphocytes to proliferate in a mixed lymphocytes reaction (MLR). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| Relation: | https://doaj.org/toc/1860-5397 |
| DOI: | 10.3762/bjoc.10.133 |
| URL الوصول: | https://doaj.org/article/82774213c0b14678a9dff4fcc0567609 |
| رقم الانضمام: | edsdoj.82774213c0b14678a9dff4fcc0567609 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
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| DOI: | 10.3762/bjoc.10.133 |