Academic Journal

Complete genomic characteristics and pathogenic analysis of the newly emerged classical swine fever virus in China

التفاصيل البيبلوغرافية
العنوان: Complete genomic characteristics and pathogenic analysis of the newly emerged classical swine fever virus in China
المؤلفون: Hongliang Zhang, Chaoliang Leng, Zhijun Tian, Chunxiao Liu, Jiazeng Chen, Yun Bai, Zhen Li, Lirun Xiang, Hongyue Zhai, Qian Wang, Jinmei Peng, Tongqing An, Yunchao Kan, Lunguang Yao, Xufu Yang, Xuehui Cai, Guangzhi Tong
المصدر: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-11 (2018)
بيانات النشر: BMC, 2018.
سنة النشر: 2018
المجموعة: LCC:Veterinary medicine
مصطلحات موضوعية: Swine, Classical swine fever virus, Sub-genotype 2.1d, Molecular characteristics, Pathogenicity, Veterinary medicine, SF600-1100
الوصف: Abstract Background Classical swine fever (CSF) is one of the most devastating and highly contagious viral diseases in the world. Since late 2014, outbreaks of a new sub-genotype 2.1d CSF virus (CSFV) had caused substantial economic losses in numbers of C-strain vaccinated swine farms in China. The objective of the present study was to explore the genomic characteristics and pathogenicity of the newly emerged CSFV isolates in China during 2014–2015. Results All the new 8 CSFV isolates belonged to genetic sub-genotype 2.1d. Some genomic variations or deletions were found in the UTRs and E2 of these new isolates. In addition, the pathogenicity of HLJ1 was less than Shimen, suggesting the HLJ1 of sub-genotype 2.1d may be a moderated pathogenic isolate and the C-strain vaccine can supply complete protection. Conclusions The new CSFV isolates with unique genomic characteristics and moderate pathogenicity can be epidemic in many large-scale C-strain vaccinated swine farms. This study provides the information should be merited special attention on establishing prevention and control policies for CSF.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1746-6148
Relation: http://link.springer.com/article/10.1186/s12917-018-1504-2; https://doaj.org/toc/1746-6148
DOI: 10.1186/s12917-018-1504-2
URL الوصول: https://doaj.org/article/818dd24b23504fbb8e9e06bef13b46cc
رقم الانضمام: edsdoj.818dd24b23504fbb8e9e06bef13b46cc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17466148
DOI:10.1186/s12917-018-1504-2