التفاصيل البيبلوغرافية
| العنوان: |
The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria–Tetanus–Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring the Roles of Heterologous Immunity |
| المؤلفون: |
Theresia Santi, Juandy Jo, Alida Roswita Harahap, Retno Asti Werdhani, Sri Rezeki S. Hadinegoro, Ivo Novita SahBandar, Ari Prayitno, Zakiudin Munasir, Yvan Vandenplas, Badriul Hegar |
| المصدر: |
Vaccines, Vol 12, Iss 9, p 1032 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
children, SARS-CoV-2-specific immune response, heterologous immunity, diphtheria–tetanus–pertussis vaccine, inactivated COVID-19 vaccine, Medicine |
| الوصف: |
Background: Routine childhood vaccination, e.g., for diphtheria, tetanus, and pertussis (DTP), might provide additional protection against SARS-CoV-2 infection. This concept of heterologous immunity was explored in healthy children receiving both DTP and inactivated SARS-CoV-2 vaccines. Methods: A cross-sectional study was performed on 154 healthy children aged 6–8 years old in Jakarta, Indonesia. Their vaccination status for the DTP (including a diphtheria–tetanus booster vaccine at 5 years old) and CoronaVac (from 6 years old) vaccines were recorded. Peripheral blood samples were collected from all participants, in which anti-diphtheria toxoid IgG and anti-SARS-CoV-2 S-RBD antibodies and T cell-derived IFN-γ were measured. Results: The study participants with complete DTP vaccination had significantly higher titers of anti-diphtheria toxoid IgG than the ones without (median = 0.9349 versus 0.2113 IU/mL; p < 0.0001). Upon stratification based on DTP and CoronaVac vaccination statuses, the participants with complete DTP and CoronaVac vaccinations had the highest titer of anti-SARS-CoV-2 S-RBD antibodies (median = 1196 U/mL) and the highest concentration of SARS-CoV-2-specific T cell-derived IFN-γ (median = 560.9 mIU/mL) among all the groups. Conclusions: Healthy children aged 6–8 years old with complete DTP and CoronaVac vaccinations exhibited stronger SARS-CoV-2-specific T cell immune responses. This might suggest an additional benefit of routine childhood vaccination in generating protection against novel pathogens, presumably via heterologous immunity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/12/9/1032; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines12091032 |
| URL الوصول: |
https://doaj.org/article/816a393831444bfc95150e335038f282 |
| رقم الانضمام: |
edsdoj.816a393831444bfc95150e335038f282 |
| قاعدة البيانات: |
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