التفاصيل البيبلوغرافية
| العنوان: |
MRI USING GADOXETIC ACID IN THE WORK-UP OF LIVER NODULES NOT CONCLUSIVELY BENIGN IN BUDD-CHIARI SYNDROME. A PROSPECTIVE LONG-TERM FOLLOW-UP |
| المؤلفون: |
Angeles Garcia-Criado, Jordi Rimola, Susana Seijo, Anna Darnell, Ernest Belmonte, Victor Sapena, Julián Moreno-Rojas, Valeria Pérez, Virginia Hernández-Gea, Carmen Ayuso, Maria Reig, Juan Carlos Garcia-Pagan, Jordi Bruix |
| المصدر: |
Liver Cancer (2023) |
| بيانات النشر: |
Karger Publishers, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Introduction The incidence of hepatocellular carcinoma (HCC) in Budd-Chiari syndrome (BCS) is unknown and there is no validated diagnostic work-up to define the liver nodules with arterial phase hyperenhancement (APHE) suggesting malignancy. This prospective study evaluates HCC incidence in a Western cohort of patients with BCS and assesses the performance of MRI with hepatobiliary contrast (HB-MRI) for nodule characterization. Methods Patients with BCS followed in our hospital were prospectively evaluated by MRI with extracellular contrast (EC-MRI). Nodules with APHE categorized as non-conclusively benign by 2 radiologists, were studied by HB-MRI and reviewed by 2 radiologists blinded to the EC-MRI results. A new EC-MRI one year later and clinical, analytical and sonographic follow-up every six months for a median of 10 years were performed. Results A total of 55 non-conclusively benign nodules with APHE were detected at EC-MRI in 41 patients. While 32 of them were suggestive of HCC by EC-MRI, all the 55 nodules showed increased uptake of hepatobiliary contrast. An unequivocal central scar was seen in 12/55 nodules at HB-MRI regardless of it was not detected on the EC-MRI. None of the nodules was hypointense in the hepatobiliary phase. HCC was not detected during a median of 10 years of follow-up. Conclusions Detection of nodules with APHE is frequent in patients with BCS, but HCC is rare in Western patients with BCS. While EC-MRI may detect nodules suggesting malignancy, the identification of contrast uptake in the hepatobiliary phase at HB-MRI may help to categorize them as benign. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-5553 |
| Relation: |
https://beta.karger.com/Article/FullText/533598; https://doaj.org/toc/1664-5553 |
| DOI: |
10.1159/000533598 |
| URL الوصول: |
https://doaj.org/article/813f99e541e045f9a8aa41600680637f |
| رقم الانضمام: |
edsdoj.813f99e541e045f9a8aa41600680637f |
| قاعدة البيانات: |
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