Academic Journal
In Vivo Anchoring Bis‐Pyrene Probe for Molecular Imaging of Early Gastric Cancer by Endoscopic Techniques
| العنوان: | In Vivo Anchoring Bis‐Pyrene Probe for Molecular Imaging of Early Gastric Cancer by Endoscopic Techniques |
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| المؤلفون: | Qiang Luo, Chaoqiang Fan, Wang Ying, Xue Peng, Yiyang Hu, Zhaohui Luan, Shaosong Ye, Chunli Gong, Yu Huang, Yufeng Xiao, Yang Chen, Malcolm Xing, Lei Wang, Shiming Yang |
| المصدر: | Advanced Science, Vol 10, Iss 4, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | blue laser endoscopy, early gastric cancer, molecular imaging, angiogenesis, Science |
| الوصف: | Abstract With the development of blue laser endoscopy (BLE) technique, it's often used to diagnose early gastric cancer (EGC) by the morphological changes of blood vessels through BLE. However, EGC is still not obvious to identify, resulting in a high rate of missed diagnosis. Molecular imaging can show the changes in early tumors at molecular level, which provides a possibility for diagnosing EGC. Therefore, developing a probe that visually monitors blood vessels of EGC under BLE is particularly necessary. Herein, a bis‐pyrene (BP) based nanoprobe (BP‐FFVLK‐(PEG)‐RGD, M1) is designed, which can target angiogenesis and self‐assemble into fibers in situ, resulting in stable and long‐term retention in tumor. Moreover, M1 probe can emit yellow‐green fluorescence for imaging under BLE. M1 probe is confirmed to steadily remain in tumor for up to 96 hours in mice transplanted subcutaneously. In addition, the M1 probe is able to target angiogenesis for molecular imaging of isolated human gastric cancer tissue under BLE. Finally, M1 probe i.v. injected into primary gastric cancer model rabbits successfully highlighted the tumor site under BLE, which is confirmed by pathological analysis. It's the first time to develop a probe for diagnosing EGC by visualizing angiogenesis under BLE, showing great clinical significance. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2198-3844 20220391 |
| Relation: | https://doaj.org/toc/2198-3844 |
| DOI: | 10.1002/advs.202203918 |
| URL الوصول: | https://doaj.org/article/e8104d4405b9403f9bf66223d886f90a |
| رقم الانضمام: | edsdoj.8104d4405b9403f9bf66223d886f90a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21983844 20220391 |
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| DOI: | 10.1002/advs.202203918 |