التفاصيل البيبلوغرافية
| العنوان: |
Protective immunity enhanced Salmonella vaccine vectors delivering Helicobacter pylori antigens reduce H. pylori stomach colonization in mice |
| المؤلفون: |
Amir Ghasemi, Shifeng Wang, Bikash Sahay, Jeffrey R. Abbott, Roy Curtiss |
| المصدر: |
Frontiers in Immunology, Vol 13 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
recombinant protein, cytokines, vaccine, protection, Helicobacter pylori, Salmonella, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Helicobacter pylori is a major cause of gastric mucosal inflammation, peptic ulcers, and gastric cancer. Emerging antimicrobial-resistant H. pylori has hampered the effective eradication of frequent chronic infections. Moreover, a safe vaccine is highly demanded due to the absence of effective vaccines against H. pylori. In this study, we employed a new innovative Protective Immunity Enhanced Salmonella Vaccine (PIESV) vector strain to deliver and express multiple H. pylori antigen genes. Immunization of mice with our vaccine delivering the HpaA, Hp-NAP, UreA and UreB antigens, provided sterile protection against H. pylori SS1 infection in 7 out of 10 tested mice. In comparison to the control groups that had received PBS or a PIESV carrying an empty vector, immunized mice exhibited specific and significant cellular recall responses and antigen-specific serum IgG1, IgG2c, total IgG and gastric IgA antibody titers. In conclusion, an improved S. Typhimurium-based live vaccine delivering four antigens shows promise as a safe and effective vaccine against H. pylori infection. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034683/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.1034683 |
| URL الوصول: |
https://doaj.org/article/80cf7c445b25432cbb3c7adc5ed5ad99 |
| رقم الانضمام: |
edsdoj.80cf7c445b25432cbb3c7adc5ed5ad99 |
| قاعدة البيانات: |
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