Academic Journal
Network meta-analysis of four common immunomodulatory therapies for the treatment of patients with thin endometrium
| العنوان: | Network meta-analysis of four common immunomodulatory therapies for the treatment of patients with thin endometrium |
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| المؤلفون: | Lifei Li, Zhijian Kou, Fei Zhao, Yan Wang, Xuehong Zhang |
| المصدر: | Gynecological Endocrinology, Vol 40, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Thin endometrium, immunomodulatory therapy, granulocyte colony-stimulating factor, platelet-rich plasma, network meta-analysis, Gynecology and obstetrics, RG1-991, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Obejective To compare the effectiveness of endometrial receptivity and pregnancy outcomes of four common immunomodulatory therapies for patients with thin endometrium.Method This systematic review and network meta-analysis using a literature search up to January 2024, to identify relevant trials comparing endometrial receptivity and pregnancy outcomes of human chorionic gonadotropin (hCG), platelet-rich plasma (PRP), infusion of granulocyte colony-stimulating factor (IG-CSF), and peripheral blood mononuclear cell (PBMC) for patients with thin endometrium. We used surface under the cumulative ranking (SUCRA) to ranked four common immunomodulatory therapies on endometrium thickness, implantation rate (IR), clinical pregnancy rate (CPR), and live birth rate (LBR). RoB2 and ROBINS-I were used to assess the certainty of evidence.Results The pooled results of 22 studies showed that hCG (mean difference [MD]: 3.05, 95% confidence interval [CI]: 1.46–4.64) and PRP (MD: 0.98, 95% CI: 0.20–1.76) significantly increase endometrium thickness. The hCG was the best among the IG-CSF (MD = −2.56, 95% CI = −4.30 to −0.82), PBMC (MD = −2.75, 95% CI = −5.49 to −0.01), and PRP (MD = −2.07, 95% CI = −3.84 to −0.30) in increasing endometrium thickness. However, IG-CSF and PRP significantly improved IR (IG-CSF: risk ratio (RR; IG-CSF: RR = 1.33, 95% CI = 1.06–1.67; PRP: RR = 1.63, 95% CI = 1.19–2.23), and LBR (IG-CSF: RR = 1.53, 95% CI = 1.16–2.02; PRP: RR = 1.59, 95% CI = 1.08–2.36).Conclusions Available evidence reveals that hCG and subcutaneous or intrauterine CSF (SG-CSF) may be the best treatment options for current thin endometrium patients. However, future high-quality and large-scale studies are necessary to validate our findings. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 09513590 1473-0766 0951-3590 |
| Relation: | https://doaj.org/toc/0951-3590; https://doaj.org/toc/1473-0766 |
| DOI: | 10.1080/09513590.2024.2360072 |
| URL الوصول: | https://doaj.org/article/e80bbe71dead449cb5f0960534804a64 |
| رقم الانضمام: | edsdoj.80bbe71dead449cb5f0960534804a64 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09513590 14730766 |
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| DOI: | 10.1080/09513590.2024.2360072 |