Academic Journal
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice
| العنوان: | Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice |
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| المؤلفون: | Yunhui Xia, Lanxiang Hao, Yueyang Li, Yifan Li, Junhan Chen, Lei Li, Xiaodong Han, Yanmei Liu, Xiaojian Wang, Dongmei Li |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 250, Iss , Pp 114497- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | 6:2 fluorotelomer alcohol (6:2 FTOH) Sertoli cells Reproductive toxicity Inflammation, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Previous studies have revealed nephrotoxicity, hepatotoxicity, subchronic developmental and reproductive toxicity in rats exposed to fluorotelomer alcohol (FTOH). However, the effects of embryonic 6:2 FTOH exposure on the reproductive system of offspring mice remain unclear. The purpose of this study is to explore the reproductive toxic effects of embryonic 6:2 FTOH exposure on offspring male mice and the related molecular mechanisms. Therefore, the pregnant mice were given corn oil or 6:2 FTOH by gavage from gestational days 12.5–21.5. The results demonstrated that embryonic 6:2 FTOH exposure resulted in disrupted testicular structure, low expression of tight junction protein between Sertoli cells (SCs), impaired blood-testis barrier (BTB) formation and maturation, reduced sperm viability and increased malformation, and induced testicular inflammation in the offspring of mice. Further in vitro studies showed that 6:2 FTOH treatment upregulated MMP-8 expression by activating AKT/NF-κB signaling pathway, which in turn enhanced occludin cleavage leading to the disruption of SCs barrier integrity. In summary, this study demonstrated that 6:2 FTOH exposure caused reproductive dysfunction in male offspring through disruption of BTB, which provided new insights into the effects of 6:2 FTOH exposure on the offspring. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651323000015; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2023.114497 |
| URL الوصول: | https://doaj.org/article/8091f90271234f4a81adc831123710d9 |
| رقم الانضمام: | edsdoj.8091f90271234f4a81adc831123710d9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2023.114497 |