Academic Journal
Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis
| العنوان: | Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis |
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| المؤلفون: | Danyal Imani, Ramazan Rezaei, Bahman Razi, Shahab Alizadeh, Mahdi Mahmoudi |
| المصدر: | Acta Medica Iranica, Vol 55, Iss 11 (2018) |
| بيانات النشر: | Tehran University of Medical Sciences, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Interleukin-6, Polymorphism, Graves, Meta-analysis, Medicine (General), R5-920 |
| الوصف: | Several studies have evaluated the association between interleukin-6 (IL-6) -174 G/C polymorphism and Graves' disease (GD); however, the results have been inconsistent. In the current study, a meta-analysis was performed to assess the association of IL6 -174 G/C polymorphism with Graves' disease. Medline, EMBASE, and Web of Science databases were searched to identify all eligible studies published before August 2016. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated to assess the strength of association in dominant, recessive, allelic, homozygotes contrast, and heterozygotes contrast models. A total of four case-control studies with 554 GD cases and 1201 healthy controls were included in this meta-analysis. In the combined analysis, the results showed significant association between the IL6 -174 G/C polymorphism and the risk for GD in dominant model (OR=1.39, 95% CI: 1.07-1.80), recessive model (OR=2.75, 95% CI: 1.01-7.55) and homozygote contrast model (OR=3.25, 95% CI: 1.1-9.58). No publication bias was found in the current study (all P>0.05). The meta-analysis results suggested that the IL6 -174 G/C polymorphism was indicated to be associated with the risk of GD. Further studies are warranted to confirm these results. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0044-6025 1735-9694 80794238 |
| Relation: | https://acta.tums.ac.ir/index.php/acta/article/view/6205; https://doaj.org/toc/0044-6025; https://doaj.org/toc/1735-9694 |
| URL الوصول: | https://doaj.org/article/c807942384eb4192b650094affc0312c |
| رقم الانضمام: | edsdoj.807942384eb4192b650094affc0312c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00446025 17359694 80794238 |
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