التفاصيل البيبلوغرافية
| العنوان: |
Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients |
| المؤلفون: |
Athanasios Metaxas, Camilla Thygesen, Sanne R. R. Briting, Anne M. Landau, Sultan Darvesh, Bente Finsen |
| المصدر: |
Frontiers in Cellular Neuroscience, Vol 13 (2019) |
| بيانات النشر: |
Frontiers Media S.A., 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
neuroinflammation, translocator protein, [3H]PK11195, synapses, synaptic vesicle glycoprotein 2A, [3H]UCB-J, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer’s disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau (pTau) tangles, neuroinflammation and synaptic loss (n = 7 subjects/group). Dense-core deposits of Aβ were present in all AD patients (7/7) and some non-demented subjects (3/7), as evidenced by 6E10 immunohistochemistry. Levels of Aβ immunoreactivity were higher in AD vs. non-AD cases. For pTau, AT8-positive neurofibrillary tangles and threads were exclusively observed in AD patient tissue. Levels of [3H]PK11195 binding to the translocator protein (TSPO), a marker of inflammatory processes, were elevated in the gray matter of AD patients compared to non-demented subjects. Levels of [3H]UCB-J binding to synaptic vesicle glycoprotein 2A (SV2A), a marker of synaptic density, were not different between groups. In AD patients, pTau immunoreactivity was positively correlated with [3H]PK11195, and negatively correlated with [3H]UCB-J binding levels. No correlation was observed between Aβ immunoreactivity and markers of neuroinflammation or synaptic density. These data demonstrate a close interplay between tau pathology, inflammation and SV2A density in AD, and provide useful information on the ability of neuroimaging biomarkers to diagnose AD dementia. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-5102 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fncel.2019.00538/full; https://doaj.org/toc/1662-5102 |
| DOI: |
10.3389/fncel.2019.00538 |
| URL الوصول: |
https://doaj.org/article/7f9a381745304dd2ba7dba1dc5242a14 |
| رقم الانضمام: |
edsdoj.7f9a381745304dd2ba7dba1dc5242a14 |
| قاعدة البيانات: |
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